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Catalog Number Size Price
LS-B16224-100 100 µg (200 µg/ml) $485 
CD1A Antibody - Human Thymus: Formalin-Fixed, Paraffin-Embedded (FFPE)
CD1A Antibody - Human Thymus: Formalin-Fixed, Paraffin-Embedded (FFPE)
CD1A Antibody - SDS-PAGE Analysis Purified CD1a Mouse Recombinant Monoclonal Antibody (rC1A/711). Confirmation of Purity and Integrity of Antibody.
CD1A Antibody - Human Thymus: Formalin-Fixed, Paraffin-Embedded (FFPE)
CD1A Antibody - Human Thymus: Formalin-Fixed, Paraffin-Embedded (FFPE)
CD1A Antibody - SDS-PAGE Analysis Purified CD1a Mouse Recombinant Monoclonal Antibody (rC1A/711). Confirmation of Purity and Integrity of Antibody.
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PathPlus™ Recombinant Monoclonal Mouse anti‑Human CD1A Antibody (clone rC1A/711, IHC) LS‑B16224

PathPlus™ Recombinant Monoclonal Mouse anti‑Human CD1A Antibody (clone rC1A/711, IHC) LS‑B16224

Note: This antibody replaces LS-C751435
Antibody:
CD1A Mouse anti-Human Recombinant Monoclonal (rC1A/711) Antibody
Application:
IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:
Price
Catalog Number
$485
LS-B16224-100
Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
CD1A Mouse anti-Human Recombinant Monoclonal (rC1A/711) Antibody
Application:
IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:

Specifications

Description
CD1a (LEU6) is an MHC class I-related glycoprotein of the CD1 family expressed on the surface of Langerhans or dendritic cells. CD1A proteins present antigens to T-cells in order to induce an immune response to certain pathogens. In addition to the response to bacterial invasion, CD1a-reactive cells have also found to regulate the immune response in individuals with bee and wasp venom allergies. Likewise, there is evidence that CD1a regulates and amplifies the inflammatory response in a number of inflammatory skin diseases. In immunohistochemistry, CD1A has membranous staining in cortical thymocytes, interdigitating reticulum cells and Langerhans cells. In cancer, CD1A stains positively in thymomas, precursor T-lymphoblastic leukemia or lymphoma, and Langerhans cell histiocytosis X. References: Eur J Immunol. 2016 Jan;46(1):56-9, PMID: 26617406; Nat Immunol. 2016 Oct;17(10):1159-66, PMID: 27548435; J Immunol. 2008 Jan 15;180(2):980-7, PMID: 18178838; J Clin Invest. 2004 Mar 1; 113(5): 658–660, PMID: 14991060
Target
Human CD1A
Synonyms
CD1A | CD1 | CD1A antigen, a polypeptide | CD1a molecule | FCB6 | HTA1 | HTa1 thymocyte antigen | R4 | T6 | CD1a antigen | Cluster of differentiation 1 A
Host
Mouse
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG1,k Recombinant Monoclonal
Clone
rC1A/711
Conjugations
Unconjugated
Purification
Protein A/G purified
Modifications
Unmodified. Also available Azide-free, Carrier-free.
Immunogen
Recombinant full-length human CD1a protein. Antigen Molecular Weight: 49 kDa
Specificity
At least five CD1 genes (CD1a, b, c, d, and e) are identified. CD1 proteins have been demonstrated to restrict T cell response to non-peptide lipid and glycolipid antigens and play a role in non-classical antigen presentation. CD1a is a non-polymorphic MHC Class 1 related cell surface glycoprotein, expressed in association with Beta-2 microglobulin. Anti-CD1a labels Langerhans cell histiocytosis (Histiocytosis X), extranodal histiocytic sarcoma, a subset of T-lymphoblastic lymphoma/leukemia, and interdigitating dendritic cell sarcoma of the lymph node.  When combined with antibodies against TTF-1 and CD5, anti-CD1a is useful in distinguishing between pulmonary and thymic neoplasms since CD1a is consistently expressed in thymic lymphocytes in both typical and atypical thymomas, but only focally in 1/6 of thymic carcinomas and not in lymphocytes in pulmonary neoplasms. Anti-CD1a is reported to be a new marker for perivascular epithelial cell tumor (PEComa).
Applications
  • IHC - Paraffin (1:50)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Usage
Immunohistology (Formalin-fixed - 0.5-1 ug/ml for 30 min at RT - Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes.) Optimal dilution for a specific application should be determined.
Presentation
10 mM PBS, 0.05% BSA, 0.05% Sodium Azide
Storage
Store at 2°C to 8°C for up to 2 years.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About CD1A
P06126 M28825 AAA51931.1

Validation

CD1A Antibody - Human Thymus: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Thymus: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Thymus: Formalin-Fixed, Paraffin-Embedded (FFPE)

CD1A Antibody - Human Thymus: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Thymus: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Thymus: Formalin-Fixed, Paraffin-Embedded (FFPE)

LSBio Ratings

PathPlus™ CD1A Antibody (clone rC1A/711) for IHC LS-B16224 has an LSBio Rating of
Laboratory Validation Score (5)

Publications (0)

Customer Reviews (0)


Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at:

Technical.Support@LSBio.com

Requested From: United States
Date Requested: 9/27/2021