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Catalog Number Size Price
LS-A2869-50 50 µg (1 mg/ml) $440 
CAV1 / Caveolin 1 Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
CAV1 / Caveolin 1 Antibody - Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE)
CAV1 / Caveolin 1 Antibody - Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
CAV1 / Caveolin 1 Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
CAV1 / Caveolin 1 Antibody - Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE)
CAV1 / Caveolin 1 Antibody - Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
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PathPlus™ Polyclonal Rabbit anti‑Human CAV1 / Caveolin 1 Antibody (N‑Terminus, IHC) LS‑A2869

PathPlus™ Polyclonal Rabbit anti‑Human CAV1 / Caveolin 1 Antibody (N‑Terminus, IHC) LS‑A2869

Note: This antibody replaces LS-C77998
Antibody:
CAV1 / Caveolin 1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Application:
IHC-P
Reactivity:
Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Guinea pig, Horse, Pig, Rabbit, Sheep
Format:
Unconjugated, Unmodified
Price
Catalog Number
$440
LS-A2869-50

Toll Free North America
206-374-1102
For Research Use Only

Overview

Antibody:
CAV1 / Caveolin 1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Application:
IHC-P
Reactivity:
Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Guinea pig, Horse, Pig, Rabbit, Sheep
Format:
Unconjugated, Unmodified

Specifications

Description
CAV1 is a scaffolding protein encoded that is a primary component of caveolae plasma membranes in most cell types. CAV1 plays an important role in cell metabolism and is involved in autophagy, fatty acid metabolism, glutaminolysis, glycolysis and mitochondrial bioenergetics. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. In cancer, CAV1 can be a driver of tumorigenesis and also a suppressor in different contexts. For example, it appears to have an oncogenic role and may be an effective target of therapy in triple negative breast cancer with aberrant TP53 expression. Conversely, higher expression of CAV1 in some liver cancer patients is associated with improved survival, and loss of CAV1 alongside APC knockout has been shown to increase colorectal tumorigenesis. In immunohistochemistry of normal tissue, it has membranous positivity in endothelial cells, adipocytes, as well as pneumocytes and basal cells of squamous epithelia in various tissues throughout the body. References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804; Onco Targets Ther. 2019; 12: 1539–1552, PMID: 30881011; Mol Cancer 15, 71 (2016), DOI:10.1186/s12943-016-0558-7; Journal of Clinical Oncology 2015 33:28_suppl, 134-134, DOI: 10.1200/jco.2015.33.28_suppl.134;
Target
Human CAV1 / Caveolin 1
Synonyms
CAV1 | Caveolin-1 | CGL3 | CAV | MSTP085 | VIP21 | BSCL3
Host
Rabbit
Reactivity
Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Guinea pig, Horse, Pig, Rabbit, Sheep (tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Synthetic 15 amino acid peptide from N-Terminus of human CAV1 / Caveolin. Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Gibbon, Baboon, Monkey, Galago, Marmoset, Mouse, Rat, Ferret, Sheep, Bovine, Dog, Cat, Bat, Horse, Rabbit, Pig, Guinea pig (100%); Elephant, Armadillo (93%).
Epitope
N-Terminus
Specificity
Human CAV1 / Caveolin. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Applications
  • IHC - Paraffin (1:100)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Usage
Immunohistochemistry: The unconjugated form was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for the unconjugated form was determined to be 3 ug/ml.
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About CAV1 / Caveolin 1
Q03135 NM_001753 NP_001744.2

Validation

CAV1 / Caveolin 1 Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)

CAV1 / Caveolin 1 Antibody - Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE)

CAV1 / Caveolin 1 Antibody - Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)

LSBio Ratings

PathPlus™ CAV1 / Caveolin 1 Antibody (N-Terminus) for IHC LS-A2869 has an LSBio Rating of
Publications (4)
Laboratory Validation Score (5)

Publications (1)

Ultrastructure and lipid composition of detergent-resistant membranes derived from mammalian sperm and two types of epithelial cells. van Gestel RA, Brouwers JF, Ultee A, Helms JB, Gadella BM. Cell and tissue research. 2016 363:129-45. (DB; Dog)

Customer Reviews (0)


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Requested From: United States
Date Requested: 7/23/2024