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Catalog Number Size Price
LS-A2171-50 50 µg (1 mg/ml) $440 
ADGRA2 / GPR124 Antibody - Breast, carcinoma
ADGRA2 / GPR124 Antibody - Lung, Non Small-Cell Carcinoma
ADGRA2 / GPR124 Antibody - Pancreas, carcinoma
ADGRA2 / GPR124 Antibody - Anti-GPR124 / TEM5 antibody IHC of human Skin, Kaposis Sarcoma Tumor Endothelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
ADGRA2 / GPR124 Antibody - Anti-GPR124 antibody IHC of human colon carcinoma, neoplastic cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
ADGRA2 / GPR124 Antibody - Anti-GPR124 / TEM5 antibody IHC of human Lung, Adenocarcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
ADGRA2 / GPR124 Antibody - Anti-GPR124 / TEM5 antibody IHC of human Prostate, Carcinoma Capillary Endothelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
ADGRA2 / GPR124 Antibody - Breast, carcinoma
ADGRA2 / GPR124 Antibody - Lung, Non Small-Cell Carcinoma
ADGRA2 / GPR124 Antibody - Pancreas, carcinoma
ADGRA2 / GPR124 Antibody - Anti-GPR124 / TEM5 antibody IHC of human Skin, Kaposis Sarcoma Tumor Endothelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
ADGRA2 / GPR124 Antibody - Anti-GPR124 antibody IHC of human colon carcinoma, neoplastic cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
ADGRA2 / GPR124 Antibody - Anti-GPR124 / TEM5 antibody IHC of human Lung, Adenocarcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
ADGRA2 / GPR124 Antibody - Anti-GPR124 / TEM5 antibody IHC of human Prostate, Carcinoma Capillary Endothelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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PathPlus™ Polyclonal Rabbit anti‑Human ADGRA2 / GPR124 Antibody (N‑Terminus, IHC) LS‑A2171

PathPlus™ Polyclonal Rabbit anti‑Human ADGRA2 / GPR124 Antibody (N‑Terminus, IHC) LS‑A2171

Antibody:
ADGRA2 / GPR124 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Application:
IHC, IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Price
Catalog Number
$440
LS-A2171-50

Toll Free North America
206-374-1102
For Research Use Only

Overview

Antibody:
ADGRA2 / GPR124 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Application:
IHC, IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified

Specifications

Description
ADGRA2 (GPR124, Tumor endothelial marker 5) is a G protein-coupled receptor that is involved in regulating cell adhesion, angiogenesis, polarity acquisition during wound healing and maintenance of the blood-brain barrier in the central nervous system. This receptor contains a leucine rich repeat (LRR), an immunoglobulin (Ig) domain, and a hormone-binding domain (HBD). The Ig domain shows similarities to motilin and titin, while the LRR domain shows similarities to LRIG1 and SLIT1-2. GPR124 can enhance WNT signaling via WNT7, and inactivation has been shown to produce defects in angiogenesis in the forebrain and ventral spinal cord. It is upregulated in the vasculature of some tumors where it likely plays a role in tumor angiogenesis. In immunohistochemistry, this receptor has membranous positivity in the vasculature of the developing liver and brain during embryogenesis. In normal and diseased tissue in adults, it highlights vascular proliferative processes (such as in granulation tissue, pyogenic granulomas and Kaposi's sarcomas) and is present on proliferating endothelial cells. It also has some limited positivity in the central nervous system. References: J Biol Chem. 2017 Jul 21;292(29):12178-12191, PMID: 28600358; Dev Cell. 2014 Oct 27;31(2):248-56, PMID: 25373781; Br J Pharmacol. 2017 Dec;174(24):4547-4563, PMID: 28244067
Target
Human ADGRA2 / GPR124
Synonyms
ADGRA2 | G protein-coupled receptor 124 | G-protein coupled receptor 124 | TEM5 | GPR124 | KIAA1531 | Tumor endothelial marker 5
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Predicted
Monkey (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Synthetic 19 amino acid peptide from N-Terminus extracellular domain of human GPR124. Percent identity with other species by BLAST analysis: Human, Gibbon (100%); Monkey, Marmoset, Elephant (95%); Gorilla, Dog, Panda (89%); Bat, Hamster, Horse, Pig (84%).
Epitope
N-Terminus
Specificity
Human GPR124. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Applications
  • IHC
  • IHC - Paraffin (2 - 5 µg/ml)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About ADGRA2 / GPR124
Q96PE1 AY181242 NP_116166.9

Validation

ADGRA2 / GPR124 Antibody - Breast, carcinoma
Breast, carcinoma
Breast, carcinoma

ADGRA2 / GPR124 Antibody - Lung, Non Small-Cell Carcinoma
Lung, Non Small-Cell Carcinoma
Lung, Non Small-Cell Carcinoma

ADGRA2 / GPR124 Antibody - Pancreas, carcinoma
Pancreas, carcinoma
Pancreas, carcinoma

ADGRA2 / GPR124 Antibody - Anti-GPR124 / TEM5 antibody IHC of human Skin, Kaposis Sarcoma Tumor Endothelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPR124 / TEM5 antibody IHC of human Skin, Kaposis Sarcoma Tumor Endothelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPR124 / TEM5 antibody IHC of human Skin, Kaposis Sarcoma Tumor Endothelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

ADGRA2 / GPR124 Antibody - Anti-GPR124 antibody IHC of human colon carcinoma, neoplastic cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPR124 antibody IHC of human colon carcinoma, neoplastic cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPR124 antibody IHC of human colon carcinoma, neoplastic cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

ADGRA2 / GPR124 Antibody - Anti-GPR124 / TEM5 antibody IHC of human Lung, Adenocarcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPR124 / TEM5 antibody IHC of human Lung, Adenocarcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPR124 / TEM5 antibody IHC of human Lung, Adenocarcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

ADGRA2 / GPR124 Antibody - Anti-GPR124 / TEM5 antibody IHC of human Prostate, Carcinoma Capillary Endothelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPR124 / TEM5 antibody IHC of human Prostate, Carcinoma Capillary Endothelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPR124 / TEM5 antibody IHC of human Prostate, Carcinoma Capillary Endothelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

LSBio Ratings

PathPlus™ ADGRA2 / GPR124 Antibody (N-Terminus) for IHC LS-A2171 has an LSBio Rating of
Laboratory Validation Score (5)

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Requested From: United States
Date Requested: 7/18/2024