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Catalog Number Size Price
LS-B16110-100 100 µg (200 mg/ml) $485 
ACPP / PAP Antibody - Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
ACPP / PAP Antibody - Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
ACPP / PAP Antibody - Human Kidney - Negative Control Tissue: Formalin-Fixed, Paraffin-Embedded (FFPE)
ACPP / PAP Antibody - SDS-PAGE Analysis Purified PSAP Mouse Monoclonal Antibody (rACPP/1338). Confirmation of Purity and Integrity of Antibody.SDS-PAGE Analysis Purified PSAP Mouse Monoclonal Antibody (rACPP/1338). Confirmation of Purity and Integrity of Antibody.
ACPP / PAP Antibody - Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
ACPP / PAP Antibody - Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
ACPP / PAP Antibody - Human Kidney - Negative Control Tissue: Formalin-Fixed, Paraffin-Embedded (FFPE)
ACPP / PAP Antibody - SDS-PAGE Analysis Purified PSAP Mouse Monoclonal Antibody (rACPP/1338). Confirmation of Purity and Integrity of Antibody.SDS-PAGE Analysis Purified PSAP Mouse Monoclonal Antibody (rACPP/1338). Confirmation of Purity and Integrity of Antibody.
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PathPlus™ Recombinant Monoclonal Mouse anti‑Human ACPP / PAP Antibody (clone rACPP/1338, IHC) LS‑B16110

PathPlus™ Recombinant Monoclonal Mouse anti‑Human ACPP / PAP Antibody (clone rACPP/1338, IHC) LS‑B16110

Note: This antibody replaces LS-C751322
Antibody:
ACPP / PAP Mouse anti-Human Recombinant Monoclonal (rACPP/1338) Antibody
Application:
IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Price
Catalog Number
$485
LS-B16110-100
Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
ACPP / PAP Mouse anti-Human Recombinant Monoclonal (rACPP/1338) Antibody
Application:
IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified

Specifications

Description
PSAP (ACPP, prostatic acid phosphatase) is a dephosphorylating enzyme produced in prostatic glandular epithelium. PSAP is a positive biomarker for hyperplastic prostate in immunohistochemistry and may be used to identify prostate origin in metastatic cancers. PSAP distinguishes prostate cancer (positive) from urothelial cancer, mesonephric remnant hyperplasia and clear cell tumors (generally negative). It is also positive in bladder and rectal carcinomas. Higher expression in tumors has been correlated with increasing tumor stage, although it is thought to be a tumor suppressant by means of vitamin D-associated slowing of prostate growth. Lower expression in normal tissue is therefore thought to be a risk factor for the development of cancer. In immunohistochemistry of normal tissue, antibodies to PSAP have cytoplasmic positivity in lysosomal granules in normal prostatic epithelial and ductal cells. References: Virchows Archiv: An International Journal of Pathology 2009-05; 454.5; 573-579, PMID: 19301031; Cancer Research 9/1/1992; 52.17; 4600-4607, PMID:1380886; The Journal of Steroid Biochemistry and Molecular Biology 2005-10; 97.43102; 37-46, PMID: 16076555; Biomolecules & Therapeutics 2013-01; 21.1; 43393, PMID: 24009853; Journal of Immunology (Baltimore, Md.: 1950) 12/15/2001; 167.12; 7150-7156, PMID: 11739538; The American Journal of Surgical Pathology 1991-08; 15.8; 785-790, PMID; 1712549; Appl Immunohistochem Mol Morphol. 2002 Sep;10(3):231-6, PMID: 12373149; Ann Diagn Pathol 2009;13:402, PMID: 19917478;
Target
Human ACPP / PAP
Synonyms
ACPP | ACP3 | 5-NT | 5-nucleotidase | Acid phosphatase, prostate | ACP-3 | Ecto-5-nucleotidase | PAP | Prostatic acid phosphatase | Thiamine monophosphatase | Prostatic acid phosphotase | TMPase
Host
Mouse
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG1,k Recombinant Monoclonal
Clone
rACPP/1338
Conjugations
Unconjugated
Purification
Protein A/G purified
Modifications
Unmodified
Immunogen
Recombinant full-length human ACPP protein. Antigen Molecular Weight: 52 kDa
Specificity
Recognizes a protein of 52 kDa , identified as prostate specific acid phosphatase (PSAP). This enzyme catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is synthesized under androgen regulation and is secreted by the epithelial cells of the prostate gland. PSAP is found in non-neoplastic adult and fetal prostatic glands, primary and metastatic prostatic carcinomas. It shows no staining in granulocytes, osteoclasts, parietal cells of the stomach, liver cells, renal cell or breast carcinomas.
Applications
  • IHC - Paraffin (1:50)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Usage
Immunohistology (Formalin-fixed - 0.5-1.0 ug/ml for 30 minutes at RT - Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes.) Optimal dilution for a specific application should be determined.
Presentation
10 mM PBS, 0.05% BSA, 0.05% Sodium Azide
Storage
Store at 2°C to 8°C for up to 2 years.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About ACPP / PAP
P15309 NM_001099 NP_001090.2

Validation

ACPP / PAP Antibody - Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)

ACPP / PAP Antibody - Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)

ACPP / PAP Antibody - Human Kidney - Negative Control Tissue: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Kidney - Negative Control Tissue: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Kidney - Negative Control Tissue: Formalin-Fixed, Paraffin-Embedded (FFPE)

LSBio Ratings

PathPlus™ ACPP / PAP Antibody (clone rACPP/1338) for IHC LS-B16110 has an LSBio Rating of
Laboratory Validation Score (5)

Publications (0)

Customer Reviews (0)


Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at:

Technical.Support@LSBio.com

Requested From: United States
Date Requested: 5/25/2022