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Catalog Number Size Price
LS-A363-50 50 µg (1 mg/ml) $460 
ACKR2 / CCR10 / D6 Antibody - Skin, Melanoma
ACKR2 / CCR10 / D6 Antibody - Anti-CCBP2 / D6 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
ACKR2 / CCR10 / D6 Antibody - Brain, Medulla
ACKR2 / CCR10 / D6 Antibody - Brain, Hippocampus CA4
ACKR2 / CCR10 / D6 Antibody - Skin, Melanoma
ACKR2 / CCR10 / D6 Antibody - Anti-CCBP2 / D6 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
ACKR2 / CCR10 / D6 Antibody - Brain, Medulla
ACKR2 / CCR10 / D6 Antibody - Brain, Hippocampus CA4
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PathPlus™ Polyclonal Rabbit anti‑Human ACKR2 / CCR10 / D6 Antibody (N‑Terminus, IHC) LS‑A363

PathPlus™ Polyclonal Rabbit anti‑Human ACKR2 / CCR10 / D6 Antibody (N‑Terminus, IHC) LS‑A363

Antibody:
ACKR2 / CCR10 / D6 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Application:
IHC, IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:
Price
Catalog Number
$460
LS-A363-50

Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
ACKR2 / CCR10 / D6 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Application:
IHC, IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:

Specifications

Description
Atypical chemokine receptor 2 (ACKR2) controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Upon active ligand stimulation, activates a beta-arrestin 1 (ARRB1)-dependent, G protein-independent signaling pathway that results in the phosphorylation of the actin-binding protein cofilin (CFL1) through a RAC1-PAK1-LIMK1 signaling pathway. Activation of this pathway results in up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804
Target
Human ACKR2 / CCR10 / D6
Synonyms
ACKR2 | C-C chemokine receptor D6 | CCBP2 | Chemokine (C-C) receptor 9 | Chemokine binding protein 2 | C-C chemokine receptor 10 | Chemokine-binding protein 2 | CMKBR9 | Chemokine receptor CCR-9 | G protein coupled receptor d6 | HD6 | Cc-chemokine receptor type 10 | Chemokine receptor CCR-10 | Chemokine receptor D6 | Chemokine-binding protein D6 | D6
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Synthetic 18 amino acid peptide from N-Terminus extracellular domain of human CCBP2 / D6. Percent identity with other species by BLAST analysis: Human (100%); Gorilla (94%); Gibbon, Marmoset (83%).
Epitope
N-Terminus
Specificity
Human CCBP2 / D6. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Applications
  • IHC
  • IHC - Paraffin (20 µg/ml)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About ACKR2 / CCR10 / D6
O00590 NM_001296 NP_001287.2

Validation

ACKR2 / CCR10 / D6 Antibody - Skin, Melanoma
Skin, Melanoma
Skin, Melanoma

ACKR2 / CCR10 / D6 Antibody - Anti-CCBP2 / D6 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-CCBP2 / D6 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-CCBP2 / D6 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

ACKR2 / CCR10 / D6 Antibody - Brain, Medulla
Brain, Medulla
Brain, Medulla

ACKR2 / CCR10 / D6 Antibody - Brain, Hippocampus CA4
Brain, Hippocampus CA4
Brain, Hippocampus CA4

LSBio Ratings

PathPlus™ ACKR2 / CCR10 / D6 Antibody (N-Terminus) for IHC LS-A363 has an LSBio Rating of
Laboratory Validation Score (5)

Publications (0)

Customer Reviews (0)


Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at:

Technical.Support@LSBio.com

Requested From: United States
Date Requested: 9/28/2021