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Catalog Number Size Price
LS-A365-50 50 µg (1 mg/ml) $460 
ACKR2 / CCR10 / D6 Antibody - Brain, Medulla
ACKR2 / CCR10 / D6 Antibody - Breast, adenocarcinoma
ACKR2 / CCR10 / D6 Antibody - Anti-CCBP2 / D6 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 24 ug/ml.
ACKR2 / CCR10 / D6 Antibody - Brain, Amygdala
ACKR2 / CCR10 / D6 Antibody - Brain, Medulla
ACKR2 / CCR10 / D6 Antibody - Breast, adenocarcinoma
ACKR2 / CCR10 / D6 Antibody - Anti-CCBP2 / D6 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 24 ug/ml.
ACKR2 / CCR10 / D6 Antibody - Brain, Amygdala
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PathPlus™ Polyclonal Rabbit anti‑Human ACKR2 / CCR10 / D6 Antibody (Internal, IHC) LS‑A365

PathPlus™ Polyclonal Rabbit anti‑Human ACKR2 / CCR10 / D6 Antibody (Internal, IHC) LS‑A365

Antibody:
ACKR2 / CCR10 / D6 Rabbit anti-Human Polyclonal (Internal) Antibody
Application:
IHC, IHC-P, ELISA
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:
Price
Catalog Number
$460
LS-A365-50

Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
ACKR2 / CCR10 / D6 Rabbit anti-Human Polyclonal (Internal) Antibody
Application:
IHC, IHC-P, ELISA
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:

Specifications

Description
Atypical chemokine receptor 2 (ACKR2) controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Upon active ligand stimulation, activates a beta-arrestin 1 (ARRB1)-dependent, G protein-independent signaling pathway that results in the phosphorylation of the actin-binding protein cofilin (CFL1) through a RAC1-PAK1-LIMK1 signaling pathway. Activation of this pathway results in up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804
Target
Human ACKR2 / CCR10 / D6
Synonyms
ACKR2 | C-C chemokine receptor D6 | CCBP2 | Chemokine (C-C) receptor 9 | Chemokine binding protein 2 | C-C chemokine receptor 10 | Chemokine-binding protein 2 | CMKBR9 | Chemokine receptor CCR-9 | G protein coupled receptor d6 | HD6 | Cc-chemokine receptor type 10 | Chemokine receptor CCR-10 | Chemokine receptor D6 | Chemokine-binding protein D6 | D6
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Synthetic 16 amino acid peptide from internal region of human CCBP2 / D6. Percent identity with other species by BLAST analysis: Human, Gibbon (100%); Gorilla (94%); Mouse, Rat, Hamster, Panda, Pig (88%); Marmoset, Dog, Bat, Rabbit (81%).
Epitope
Internal
Specificity
Human CCBP2 / D6. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Applications
  • IHC
  • IHC - Paraffin (24 µg/ml)
  • ELISA
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About ACKR2 / CCR10 / D6
O00590 NM_001296 NP_001287.2

Validation

ACKR2 / CCR10 / D6 Antibody - Brain, Medulla
Brain, Medulla
Brain, Medulla

ACKR2 / CCR10 / D6 Antibody - Breast, adenocarcinoma
Breast, adenocarcinoma
Breast, adenocarcinoma

ACKR2 / CCR10 / D6 Antibody - Anti-CCBP2 / D6 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 24 ug/ml.
Anti-CCBP2 / D6 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 24 ug/ml.
Anti-CCBP2 / D6 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 24 ug/ml.

ACKR2 / CCR10 / D6 Antibody - Brain, Amygdala
Brain, Amygdala
Brain, Amygdala

LSBio Ratings

PathPlus™ ACKR2 / CCR10 / D6 Antibody (Internal) for IHC, ELISA LS-A365 has an LSBio Rating of
Laboratory Validation Score (5)

Publications (0)

Customer Reviews (0)


Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at:

Technical.Support@LSBio.com

Requested From: United States
Date Requested: 9/19/2021