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Catalog Number Size Price
LS-A9381-50 50 µg (1 mg/ml) $425 
ITGAX / CD11c Antibody - Anti-CD11c antibody IHC of human colon, neutrophils. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

PathPlus™ Polyclonal ITGAX / CD11c Antibody (Internal, IHC) LS‑A9381

PathPlus™ Polyclonal ITGAX / CD11c Antibody (Internal, IHC) LS‑A9381

Antibody:
Rabbit Polyclonal to Human ITGAX / CD11c
Application:
IHC, IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:
Price
Catalog Number
$425 
LS-A9381-50
50 µg
1 mg/ml

Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
Rabbit Polyclonal to Human ITGAX / CD11c
Application:
IHC, IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:

Specifications

Description
ITGAX (CD11c) is the integrin alpha X chain protein that functions as a fibrinogen receptor. ITGAX plays a role in monocyte adhesion and chemotaxis, and can induce cellular activation and trigger neutrophil respiratory burst. In cancer, it is positive in leukemia, including the hairy cell, acute nonlymphocytic and B-cell chronic lymphocytic subtypes, and follicular and lymphoplasmacytic lymphoma. In obesity, CD206 and TGAX / CD11c positive macrophages in adipose tissue are correlated with insulin resistance. In immunohistochemistry, ITGAX is found on dendritic cells, monocytes, granulocytes, macrophages, neutrophils, some B cells, as well as roughly half of activated CD4 and CD8 positive T cells. It is commonly used to identify histiocytes and NK cells, and also in the diagnosis of leukemia. References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804; Diabetes 2010;59:1648, PMID: 20357360; McKusick, Hamosh. Online Mendelian Inheritance in Man, OMIM. Johns Hopkins University, Baltimore, MD. MIM Number: 151510, URL: https://omim.org/ OMIM: 151510; Am J Clin Pathol 2005;124:414, PMID: 16191510; Am J Clin Pathol 1998;110:582, PMID: 9802342;
Target
Human ITGAX / CD11c
Synonyms
ITGAX | CD11c antigen | Integrin alpha-X | Leu M5, alpha subunit | p150 95 integrin alpha chain | SLEB6 | CD11C | Leu M5
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (20 µg/ml)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
Synthetic 14 amino acid peptide from internal region of human CD11c. Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Gibbon (93%).
Blocking Peptide
LS-E29623 - Liquid - 50 µg - $145.00
Immunizing peptide used to generate LS-A9381. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
Epitope
Internal
Specificity
Human CD11c. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except TDO2 (57%).
Usage
Immunohistochemistry: The unconjugated form was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for the unconjugated form was determined to be 20 ug/ml.
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About ITGAX / CD11c
P20702 NM_000887 NP_000878.2

Validation

ITGAX / CD11c Antibody - Anti-CD11c antibody IHC of human colon, neutrophils. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-CD11c antibody IHC of human colon, neutrophils. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-CD11c antibody IHC of human colon, neutrophils. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

LSBio Ratings

PathPlus™ ITGAX / CD11c Antibody (Internal) for IHC LS-A9381 has an LSBio Rating of
Laboratory Validation Score (5)

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Requested From: United States
Date Requested: 3/28/2020