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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Cell Cycle Pathways
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Catalog Number Size Price
LS-B4345-50 50 µg (0.5 mg/ml) $425 
SLC7A11 / XCT Antibody - Anti-SLC7A11 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
SLC7A11 / XCT Antibody - Anti-SLC7A11 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
SLC7A11 / XCT Antibody - Goat Anti-SLC7A11 Antibody Immunofluorescence analysis of paraformaldehyde fixed A549 cells, permeabilized with 0.15% Triton. Primary incubation 1hr (10ug/ml) followed by Alexa Fluor 488 secondary antibody (2ug/ml), showing vesicle/cytoplasmic staining. The nuclear stain is DAPI (blue). Negative control: Unimmunized goat IgG (10ug/ml) followed by Alexa Fluor 488 secondary antibody (2ug/ml).
SLC7A11 / XCT Antibody - Goat Anti-SLC7A11 Antibody (0.1µg/ml) staining of Human Smooth Muscle (A) and Tonsil (B) lysate (35µg protein in RIPA buffer). Detected by chemiluminescencence.
SLC7A11 / XCT Antibody - Goat Anti-SLC7A11 Antibody (0.3µg/ml) staining of A549 (A) and U2OS (B) cell ysate (35µg protein in RIPA buffer). Detected by chemiluminescencence.
SLC7A11 / XCT Antibody - Goat Anti-SLC7A11 Antibody Flow cytometric analysis of paraformaldehyde fixed A549 cells (blue line), permeabilized with 0.5% Triton. Primary incubation 1hr (10ug/ml) followed by Alexa Fluor 488 secondary antibody (1ug/ml). IgG control: Unimmunized goat IgG (black line) followed by Alexa Fluor 488 secondary antibody.
SLC7A11 / XCT Antibody - Anti-SLC7A11 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
SLC7A11 / XCT Antibody - Anti-SLC7A11 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
SLC7A11 / XCT Antibody - Goat Anti-SLC7A11 Antibody Immunofluorescence analysis of paraformaldehyde fixed A549 cells, permeabilized with 0.15% Triton. Primary incubation 1hr (10ug/ml) followed by Alexa Fluor 488 secondary antibody (2ug/ml), showing vesicle/cytoplasmic staining. The nuclear stain is DAPI (blue). Negative control: Unimmunized goat IgG (10ug/ml) followed by Alexa Fluor 488 secondary antibody (2ug/ml).
SLC7A11 / XCT Antibody - Goat Anti-SLC7A11 Antibody (0.1µg/ml) staining of Human Smooth Muscle (A) and Tonsil (B) lysate (35µg protein in RIPA buffer). Detected by chemiluminescencence.
SLC7A11 / XCT Antibody - Goat Anti-SLC7A11 Antibody (0.3µg/ml) staining of A549 (A) and U2OS (B) cell ysate (35µg protein in RIPA buffer). Detected by chemiluminescencence.
SLC7A11 / XCT Antibody - Goat Anti-SLC7A11 Antibody Flow cytometric analysis of paraformaldehyde fixed A549 cells (blue line), permeabilized with 0.5% Triton. Primary incubation 1hr (10ug/ml) followed by Alexa Fluor 488 secondary antibody (1ug/ml). IgG control: Unimmunized goat IgG (black line) followed by Alexa Fluor 488 secondary antibody.
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PathPlus™ Polyclonal Goat anti‑Human SLC7A11 / XCT Antibody (aa215‑229, IHC, IF, WB) LS‑B4345

PathPlus™ Polyclonal Goat anti‑Human SLC7A11 / XCT Antibody (aa215‑229, IHC, IF, WB) LS‑B4345

Note: This antibody replaces LS-C55476
Antibody:
Goat Polyclonal to Human SLC7A11 / XCT
Application:
IHC, IHC-P, IF, WB, Peptide-ELISA
Reactivity:
Human, Monkey
Format:
Unconjugated, Unmodified
Price
Catalog Number
$425 
LS-B4345-50
50 µg
0.5 mg/ml
Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
Goat Polyclonal to Human SLC7A11 / XCT
Application:
IHC, IHC-P, IF, WB, Peptide-ELISA
Reactivity:
Human, Monkey
Format:
Unconjugated, Unmodified

Specifications

Description
SLC7A11 (cystine/glutamate transporter, Xc-, xCT) is a chloride-dependent cystine-glutamate antiporter involved in excitatory signaling, glutamate release and modulation of synaptic activity. In addition to glutamatergic neurotransmission, it is thought to support neuroprotective processes related to oxidative stress. Dysfunctional glutamate signaling in neurological disorders such as schizophrenia may involve impairment of SLC7A11. In immunohistochemistry, SLC7A11 has high expression in astrocytes of the basolateral amygdala and prefrontal cortex in the brain, and it is also found in the eye, with low levels of additional expression in immune, reproductive and gastrointestinal tissues. References: Pharmacological Reviews. 64 (3): 780–802, PMID: 22759795; Journal of Psychiatric Research. 72: 58–63, PMID: 26540405; Glia. 2018 May;66(5):951-970, PMID: 29350434; NPJ Schizophr. 2017 Sep 18;3(1):31, PMID: 28924227; Antioxid Redox Signal. 2013 Feb 10; 18(5): 522–555, PMID: 22667998
Target
Human SLC7A11 / XCT
Synonyms
SLC7A11 | CCBR1 | Cystine/glutamate transporter | XCT | SLC711
Host
Goat
Reactivity
Human, Monkey (tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (3.75 µg/ml)
  • Immunofluorescence (10 µg/ml)
  • Western blot (0.03 - 0.3 µg/ml)
  • Peptide Enzyme-Linked Immunosorbent Assay (1:128000)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
Peptide with sequence C-KGQTQNFKDAFSGRD, from the internal region of the protein sequence according to NP_055146.1.
Blocking Peptide
LS-E26198 - Lyophilized - 100 µg - $145.00
Immunizing peptide used to generate LS-B4345. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
Epitope
aa215-229
Specificity
Human SLC7A11.
Presentation
TBS, pH 7.3, 0.02% Sodium Azide, 0.5% BSA
Storage
Aliquot and store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About SLC7A11 / XCT
Q9UPY5 NM_014331 NP_055146.1

Validation

SLC7A11 / XCT Antibody - Anti-SLC7A11 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
Anti-SLC7A11 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
Anti-SLC7A11 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.

SLC7A11 / XCT Antibody - Anti-SLC7A11 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
Anti-SLC7A11 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
Anti-SLC7A11 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.

LSBio Ratings

PathPlus™ SLC7A11 / XCT Antibody (aa215-229) for IHC, IF/Immunofluorescence, WB/Western LS-B4345 has an LSBio Rating of
Publications (4)
Laboratory Validation Score (5)

Publications (1)

Increased Expression of System xc- in Glioblastoma Confers an Altered Metabolic State and Temozolomide Resistance. Polewski MD, Reveron-Thornton RF, Cherryholmes GA, Marinov GK, Cassady K, Aboody KS. Molecular cancer research : MCR. 2016 December;14:1229-1242. (Human)

Customer Reviews (0)


Requested From: United States
Date Requested: 7/11/2020