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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Cell Cycle Pathways
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Catalog Number Size Price
LS-A7220-50 50 µg (1 mg/ml) $425 
SGK2 Antibody - Anti-SGK2 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
SGK2 Antibody - Ovary, Carcinoma
SGK2 Antibody - Skin, Malignant Melanoma
SGK2 Antibody - Anti-SGK2 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
SGK2 Antibody - Anti-SGK2 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
SGK2 Antibody - Anti-SGK2 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
SGK2 Antibody - Anti-SGK2 antibody IHC of human Lung, Non-Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
SGK2 Antibody - Anti-SGK2 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
SGK2 Antibody - Ovary, Carcinoma
SGK2 Antibody - Skin, Malignant Melanoma
SGK2 Antibody - Anti-SGK2 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
SGK2 Antibody - Anti-SGK2 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
SGK2 Antibody - Anti-SGK2 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
SGK2 Antibody - Anti-SGK2 antibody IHC of human Lung, Non-Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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PathPlus™ Polyclonal Rabbit anti‑Human SGK2 Antibody (Kinase Domain, IHC) LS‑A7220

PathPlus™ Polyclonal Rabbit anti‑Human SGK2 Antibody (Kinase Domain, IHC) LS‑A7220

Antibody:
Rabbit Polyclonal to Human SGK2
Application:
IHC, IHC-P, ELISA
Reactivity:
Human, Bovine
Format:
Unconjugated, Unmodified
Other formats:
Price
Catalog Number
$425 
LS-A7220-50
50 µg
1 mg/ml

Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
Rabbit Polyclonal to Human SGK2
Application:
IHC, IHC-P, ELISA
Reactivity:
Human, Bovine
Format:
Unconjugated, Unmodified
Other formats:

Specifications

Description
SGK2 is a serine/threonine-protein kinase that modulates the expression of a wide variety of ion channels, membrane transporters, cell growth, survival and proliferation. It upregulates Na+ channel SCNN1A (ENAC), K+ channels KCNA3 (Kv1.3), KCNE1 and KCNQ1, amino acid transporter SLC6A19, glutamate transporter SLC1A6 (EAAT4), glutamate receptors GRIA1 (GLUR1) and GRIK2 (GLUR6), Na+/H+ exchanger SLC9A3 (NHE3), and the Na+/K+ ATPase. It also regulates the human organic anion transporter 4 (OAT4) via NEDD4. In immunohistochemistry, it has high expression in kidney proximal tubule cells, and is also found in the gastrointestinal tract, liver, pancreas, skeletal muscle, brain, adrenal and thyroid glands, skin, appendix and spleen, and in reproductive tissues. References: Biochem Pharmacol. 2016 Feb 15;102:120-129, PMID: 26740304
Target
Human SGK2
Synonyms
SGK2 | DJ138B7.2 | H-SGK2 | Hsgk2
Host
Rabbit
Reactivity
Human, Bovine (tested or 100% immunogen sequence identity)
Predicted
Monkey, Dog, Horse, Rabbit (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (10 µg/ml)
  • ELISA
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
Synthetic 15 amino acid peptide from kinase domain of human SGK2. Percent identity with other species by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Monkey, Bovine (100%); Marmoset, Dog, Horse, Rabbit, Platypus (93%); Bat, Elephant, Panda, Opossum, Turkey, Chicken (87%); Xenopus (80%).
Blocking Peptide
LS-E29242 - Liquid - 50 µg - $145.00
Immunizing peptide used to generate LS-A7220. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
Epitope
Kinase Domain
Specificity
Human SGK2. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except SGK3 (67%).
Usage
Immunohistochemistry: The unconjugated form was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after proteinase K antigen retrieval. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for the unconjugated form was determined to be 5 ug/ml.
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About SGK2
Q9HBY8 NM_016276 NP_057360.2

Validation

SGK2 Antibody - Anti-SGK2 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-SGK2 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-SGK2 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

SGK2 Antibody - Ovary, Carcinoma
Ovary, Carcinoma
Ovary, Carcinoma

SGK2 Antibody - Skin, Malignant Melanoma
Skin, Malignant Melanoma
Skin, Malignant Melanoma

SGK2 Antibody - Anti-SGK2 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-SGK2 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-SGK2 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

SGK2 Antibody - Anti-SGK2 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-SGK2 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-SGK2 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

SGK2 Antibody - Anti-SGK2 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-SGK2 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-SGK2 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

SGK2 Antibody - Anti-SGK2 antibody IHC of human Lung, Non-Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-SGK2 antibody IHC of human Lung, Non-Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-SGK2 antibody IHC of human Lung, Non-Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

LSBio Ratings

PathPlus™ SGK2 Antibody (Kinase Domain) for IHC, ELISA LS-A7220 has an LSBio Rating of
Laboratory Validation Score (5)

Publications (0)

Customer Reviews (0)


Requested From: United States
Date Requested: 6/5/2020