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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Catalog Number Size Price
LS-A6795-50 50 µg (1 mg/ml) $425 
PTPRA / RPTP-Alpha Antibody - Breast, Carcinoma
PTPRA / RPTP-Alpha Antibody - Lung, Non Small-Cell Carcinoma
PTPRA / RPTP-Alpha Antibody - Skin, Malignant Melanoma
PTPRA / RPTP-Alpha Antibody - Anti-PTPRA antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 4 ug/ml.
PTPRA / RPTP-Alpha Antibody - Anti-PTPRA / RPTP-Alpha antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
PTPRA / RPTP-Alpha Antibody - Anti-PTPRA antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 4 ug/ml.
PTPRA / RPTP-Alpha Antibody - Breast, Carcinoma
PTPRA / RPTP-Alpha Antibody - Lung, Non Small-Cell Carcinoma
PTPRA / RPTP-Alpha Antibody - Skin, Malignant Melanoma
PTPRA / RPTP-Alpha Antibody - Anti-PTPRA antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 4 ug/ml.
PTPRA / RPTP-Alpha Antibody - Anti-PTPRA / RPTP-Alpha antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
PTPRA / RPTP-Alpha Antibody - Anti-PTPRA antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 4 ug/ml.
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PathPlus™ Polyclonal PTPRA / RPTP‑Alpha Antibody (Extracellular Domain, IHC) LS‑A6795

PathPlus™ Polyclonal PTPRA / RPTP‑Alpha Antibody (Extracellular Domain, IHC) LS‑A6795

Antibody:
Rabbit Polyclonal to Human PTPRA / RPTP-Alpha
Application:
IHC, IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:
Price
Catalog Number
$425 
LS-A6795-50
50 µg
1 mg/ml

Toll Free North America
866-819-4732

Overview

Antibody:
Rabbit Polyclonal to Human PTPRA / RPTP-Alpha
Application:
IHC, IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:

Specifications

Description
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported. References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804
Target
Human PTPRA / RPTP-Alpha
Synonyms
PTPRA | HLPR | Hptp alpha | HEPTP | HPTPA | PTPA | Ptpalpha | PTPRL2 | PTP alpha | PTPLCA-related phosphatase | R-PTP-alpha | RPTPA | Rptpalpha | Tyrosine phosphatase alpha | RPTP alpha | HPTPalpha | LRP | PTPase-alpha
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Predicted
Monkey, Rat (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (15 µg/ml)
  • Applications tested for the base form of this product only
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
Synthetic 17 amino acid peptide from extracellular domain of human PTPRA. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey (100%); Marmoset, Rat (94%); Hamster, Dog, Bovine, Rabbit (88%); Mouse, Panda, Horse (82%).
Blocking Peptide
LS-E29185 - Liquid - 50 µg - $145.00
Immunizing peptide used to generate LS-A6795. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
Epitope
Extracellular Domain
Specificity
Human PTPRA. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except HLA-S (59%).
Usage
Immunohistochemistry: The unconjugated form was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for the unconjugated form was determined to be 15 ug/ml.
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About PTPRA / RPTP-Alpha
P18433 NM_002836 NP_002827.1

Validation

PTPRA / RPTP-Alpha Antibody - Breast, Carcinoma
Breast, Carcinoma
Breast, Carcinoma

PTPRA / RPTP-Alpha Antibody - Lung, Non Small-Cell Carcinoma
Lung, Non Small-Cell Carcinoma
Lung, Non Small-Cell Carcinoma

PTPRA / RPTP-Alpha Antibody - Skin, Malignant Melanoma
Skin, Malignant Melanoma
Skin, Malignant Melanoma

PTPRA / RPTP-Alpha Antibody - Anti-PTPRA antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 4 ug/ml.
Anti-PTPRA antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 4 ug/ml.
Anti-PTPRA antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 4 ug/ml.

PTPRA / RPTP-Alpha Antibody - Anti-PTPRA / RPTP-Alpha antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-PTPRA / RPTP-Alpha antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-PTPRA / RPTP-Alpha antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

PTPRA / RPTP-Alpha Antibody - Anti-PTPRA antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 4 ug/ml.
Anti-PTPRA antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 4 ug/ml.
Anti-PTPRA antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 4 ug/ml.

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Requested From: United States
Date Requested: 2/27/2020