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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Catalog Number Size Price
LS-B7184-0.05 0.05 mg (1 mg/ml) $425 
NEFM / NF-M Antibody - Anti-NEFM / NF-M antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
NEFM / NF-M Antibody - Indirect immunofluorescence staining of rat brain tissue section with NEFM / NF-M
NEFM / NF-M Antibody - Indirect immunofluorescence staining of rat brain tissue section with NEFM / NF-M
NEFM / NF-M Antibody - Anti-NEFM / NF-M antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
NEFM / NF-M Antibody - Indirect immunofluorescence staining of rat brain tissue section with NEFM / NF-M
NEFM / NF-M Antibody - Indirect immunofluorescence staining of rat brain tissue section with NEFM / NF-M
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PathPlus™ NEFM / NF‑M Antibody Monoclonal Flo,IHC,WB LS‑B7184

PathPlus™ NEFM / NF‑M Antibody Monoclonal Flo,IHC,WB LS‑B7184

Note: This antibody replaces LS-C146778, LS-C150508
Antibody:
Mouse Monoclonal to Human NEFM / NF-M
Application:
IHC, IHC-P, IHC-Fr, WB, Flo
Reactivity:
Human, Monkey, Guinea pig, Hamster, Rabbit, Xenopus
Format:
Unconjugated, Unmodified
Price
Catalog Number
$425 
LS-B7184-0.05
0.05 mg
1 mg/ml
Toll Free North America
866-819-4732

Overview

Antibody:
Mouse Monoclonal to Human NEFM / NF-M
Application:
IHC, IHC-P, IHC-Fr, WB, Flo
Reactivity:
Human, Monkey, Guinea pig, Hamster, Rabbit, Xenopus
Format:
Unconjugated, Unmodified

Specifications

Description
NEFM is an intermediate filament component of the neurofilament heteropolymers that form the neuronal cytoskeleton together with microtubules. Neurofilaments act as structural space-fillers for axons and are also involved in axonal transport. Antibodies that detect NEFM are regularly used to identify neurons and distinguish them from glia (neurofilament-negative) and for diagnosis in neuropathology. Because neurofilaments are released into the blood when axons and neurons deteriorate, antibodies to neurofilaments are also used to observe the progression and state of neurodegenerative diseases such as multiple sclerosis and Huntington’s disease, and NEFM is a common biomarker of neuronal damage. In immunohistochemistry, NEFM antibodies highlight axons of neuronal cells in the central nervous system and in peripheral nerves. European Journal of Neurology. 2010 Mar. 17 (3): 377–8, PMID: 19845747; Neurology. 2009 Apr. 72 (15): 1322–9, PMID: 19365053; PLOS One. 2017 Feb. 12 (2): e0172762, PMID: 28241046; Garland Science. ISBN: 978-0-8153-3218-3.
Target
Human NEFM / NF-M
Host
Mouse
Reactivity
Human, Monkey, Guinea pig, Hamster, Rabbit, Xenopus (tested or 100% immunogen sequence identity)
Clonality
IgG1 Monoclonal
Clone
RNF406
Conjugations
Unconjugated
Purification
Purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (10 µg/ml)
  • IHC - Frozen (1:50 - 1:100)
  • Western blot (1:100 - 1:500)
  • Flow Cytometry (1:50 - 1:100)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
Neurofilament preparation of calf brain tissue.
Specificity
Reacts exclusively with the phosphorylated isoform of the160 kD neurofilament protein.
Presentation
PBS, 0.09% Sodium Azide
Storage
Short term: store at 4°C. Long term: aliquot and store at -20°C. Avoid freeze-thaw cycles. Store undiluted.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About NEFM / NF-M
P07197 NM_005382 NP_005373.2

Validation

NEFM / NF-M Antibody - Anti-NEFM / NF-M antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Anti-NEFM / NF-M antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Anti-NEFM / NF-M antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.

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Requested From: United States
Date Requested: 11/20/2019