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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Catalog Number Size Price
LS-B7678-50 50 µl (1 mg/ml) $425 
IGSF4C / CADM4 Antibody - Anti-IGSF4C / CADM4 antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 10 ug/ml.
IGSF4C / CADM4 Antibody - Immunofluorescence analysis of A549 cells, using CADM4 Antibody. The picture on the right is blocked with the synthesized peptide.
IGSF4C / CADM4 Antibody - Western blot analysis of lysates from RAW264.7 cells, using CADM4 Antibody. The lane on the right is blocked with the synthesized peptide.
IGSF4C / CADM4 Antibody - Anti-IGSF4C / CADM4 antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 10 ug/ml.
IGSF4C / CADM4 Antibody - Immunofluorescence analysis of A549 cells, using CADM4 Antibody. The picture on the right is blocked with the synthesized peptide.
IGSF4C / CADM4 Antibody - Western blot analysis of lysates from RAW264.7 cells, using CADM4 Antibody. The lane on the right is blocked with the synthesized peptide.
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PathPlus™ IGSF4C / CADM4 Antibody aa339‑388 Polyclonal IF,IHC,Peptide‑ELISA,WB LS‑B7678

PathPlus™ IGSF4C / CADM4 Antibody aa339‑388 Polyclonal IF,IHC,Peptide‑ELISA,WB LS‑B7678

Note: This antibody replaces LS-C119425
Antibody:
Rabbit Polyclonal to Human IGSF4C / CADM4
Application:
IHC, IHC-P, IF, WB, Peptide-ELISA
Reactivity:
Human, Mouse, Rat
Format:
Unconjugated, Unmodified
Price
Catalog Number
$425 
LS-B7678-50
50 µl
1 mg/ml
Toll Free North America
866-819-4732

Overview

Antibody:
Rabbit Polyclonal to Human IGSF4C / CADM4
Application:
IHC, IHC-P, IF, WB, Peptide-ELISA
Reactivity:
Human, Mouse, Rat
Format:
Unconjugated, Unmodified

Specifications

Description
CADM4 (Cell adhesion molecule 4, IGSF4C, TSLL2) is a membrane glycoprotein of the immunoglobulin superfamily. It is involved in cell-cell interaction, adhesion, regulation of contact inhibition and proliferation. It is expressed in glia and axons, where it functions in Schwann cell and axon interaction. It is also important for the development of the myelin unit in the peripheral nervous system, and absence of CADM4 leads to myelin abnormalities akin to those in Charcot-Marie-Tooth syndrome. CADM4 is thought to be involved in tumor suppression, and expression is lost in breast carcinomas, prostate carcinomas, renal carcinomas and gliomas. In immunohistochemistry, CADM4 has highest cytoplasmic and membranous positivity in neurons in the cerebral cortex, followed by positivity in cell-cell attachment sites in proximal renal tubules, the glandular epithelia of the prostate, the transitional epithelia of the bladder, and a few additional tissues. PLoS One. 2015; 10(4): e0124259, PMID: 25893857; Oncogene. 2006 Mar 9;25(10):1446-53, PMID: 16261159; Int J Cancer. 2012 Mar 15;130(6):1329-37, PMID: 21544807; Oncol Lett. 2018 Feb; 15(2): 2401–2406, PMID: 29434950; J Neurosci. 2013 Jul 3;33(27):10950-61, PMID: 23825401
Target
Human IGSF4C / CADM4
Host
Rabbit
Reactivity
Human, Mouse, Rat (tested or 100% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (1:100)
  • Immunofluorescence (1:100 - 1:500)
  • Western blot (1:500 - 1:1000)
  • Peptide Enzyme-Linked Immunosorbent Assay (1:20000)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
Synthetic peptide from human CADM4. (AA Range: 339-388)
Epitope
aa339-388
Specificity
CADM4 Antibody detects endogenous levels of total CADM4 protein.
Usage
Western Blot: Predicted MW 42 kDa
Presentation
PBS (without Mg2+, Ca2+), pH 7.4, 150 mM NaCl, 0.02% Sodium Azide, 50% Glycerol
Storage
Store at -20°C for up to 1 year.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About IGSF4C / CADM4
Q8NFZ8 NM_145296 NP_660339.1

Validation

IGSF4C / CADM4 Antibody - Anti-IGSF4C / CADM4 antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 10 ug/ml.
Anti-IGSF4C / CADM4 antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 10 ug/ml.
Anti-IGSF4C / CADM4 antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 10 ug/ml.

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Requested From: United States
Date Requested: 11/15/2019