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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Cell Cycle Pathways
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Catalog Number Size Price
LS-B4340-50 50 µg $495 
HCLS1 Antibody - Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
HCLS1 Antibody - Human Thymus: Formalin-Fixed, Paraffin-Embedded (FFPE)
HCLS1 Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
HCLS1 Antibody - HCLS1 monoclonal antibody, clone 2A8 Western blot of HCLS1 expression in K-562.
HCLS1 Antibody - Detection limit for recombinant GST tagged HCLS1 is approximately 0.3 ng/ml as a capture antibody.
HCLS1 Antibody - Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
HCLS1 Antibody - Human Thymus: Formalin-Fixed, Paraffin-Embedded (FFPE)
HCLS1 Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
HCLS1 Antibody - HCLS1 monoclonal antibody, clone 2A8 Western blot of HCLS1 expression in K-562.
HCLS1 Antibody - Detection limit for recombinant GST tagged HCLS1 is approximately 0.3 ng/ml as a capture antibody.
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PathPlus™ Monoclonal Mouse anti‑Human HCLS1 Antibody (clone 2A8, IHC, WB) LS‑B4340

PathPlus™ Monoclonal Mouse anti‑Human HCLS1 Antibody (clone 2A8, IHC, WB) LS‑B4340

Note: This antibody replaces LS-C104964
Antibody:
Mouse Monoclonal to Human HCLS1
Application:
IHC, IHC-P, WB, ELISA
Reactivity:
Human
Format:
Unconjugated, Unmodified
Price
Catalog Number
$495 
LS-B4340-50
50 µg
Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
Mouse Monoclonal to Human HCLS1
Application:
IHC, IHC-P, WB, ELISA
Reactivity:
Human
Format:
Unconjugated, Unmodified

Specifications

Description
HCLS1 (Hematopoietic cell-specific Lyn substrate 1) is an actin-binding substrate of the antigen receptor-coupled tyrosine kinase expressed in leukocytes that functions in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. It regulates ARP2/ARP3-dependent migration of leukocytes and is a direct actin modulator. It also regulates a number of downstream receptors including TCR, CXCR4 and BCR. HCLS1 is also an effective prognostic marker for ovarian carcinoma, where it is involved in cytoskeleton remodeling, cell migration and invasion and where positivity is associated with worse survival. In immunohistochemistry of normal tissue, it has cytoplasmic and membranous positivity in cells of hematopoietic origin and in immune tissues. References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804; J Leukoc Biol. 2019 May;105(5):881-890, PMID: 30537294; Oncotarget. 2018 Aug 24; 9(66): 32609–32623, PMID: 30220969
Target
Human HCLS1
Synonyms
HCLS1 | CTTNL | LckBP1 | p75 | HS1
Host
Mouse
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG1,k Monoclonal
Clone
2A8
Conjugations
Unconjugated
Purification
Purified from ascites by Protein A
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (5 µg/ml)
  • Western blot
  • ELISA
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
HCLS1 (AAH16758, 266 aa ~ 356 aa) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Usage
Western Blot (Cell lysate) - positive control K-562. ELISA (Recombinant protein).
Presentation
PBS, pH 7.4
Storage
Store at -20°C. Aliquot to avoid freeze/thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About HCLS1
P14317 NM_005335 NP_005326.2

Validation

HCLS1 Antibody - Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)

HCLS1 Antibody - Human Thymus: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Thymus: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Thymus: Formalin-Fixed, Paraffin-Embedded (FFPE)

HCLS1 Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)

LSBio Ratings

PathPlus™ HCLS1 Antibody (clone 2A8) for IHC, WB/Western, ELISA LS-B4340 has an LSBio Rating of
Laboratory Validation Score (5)

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Requested From: United States
Date Requested: 7/12/2020