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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Catalog Number Size Price
LS-A3552-50 50 µg (1 mg/ml) $425 
GPRC5A / RAI3 Antibody - Colon, Carcinoma
GPRC5A / RAI3 Antibody - Breast carcinoma
GPRC5A / RAI3 Antibody - Ovary, Carcinoma
GPRC5A / RAI3 Antibody - Lung, Non Small-Cell Carcinoma
GPRC5A / RAI3 Antibody - Anti-GPRC5A / RAI3 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
GPRC5A / RAI3 Antibody - Anti-GPRC5A / RAI3 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
GPRC5A / RAI3 Antibody - Anti-GPRC5A / RAI3 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
GPRC5A / RAI3 Antibody - Anti-GPRC5A / RAI3 antibody IHC of human Pancreas, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
GPRC5A / RAI3 Antibody - Breast, Carcinoma
GPRC5A / RAI3 Antibody - Colon, Carcinoma
GPRC5A / RAI3 Antibody - Breast carcinoma
GPRC5A / RAI3 Antibody - Ovary, Carcinoma
GPRC5A / RAI3 Antibody - Lung, Non Small-Cell Carcinoma
GPRC5A / RAI3 Antibody - Anti-GPRC5A / RAI3 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
GPRC5A / RAI3 Antibody - Anti-GPRC5A / RAI3 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
GPRC5A / RAI3 Antibody - Anti-GPRC5A / RAI3 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
GPRC5A / RAI3 Antibody - Anti-GPRC5A / RAI3 antibody IHC of human Pancreas, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
GPRC5A / RAI3 Antibody - Breast, Carcinoma
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PathPlus™ Polyclonal GPRC5A / RAI3 Antibody (Transmembrane Domain, IHC) LS‑A3552

PathPlus™ Polyclonal GPRC5A / RAI3 Antibody (Transmembrane Domain, IHC) LS‑A3552

Note: This antibody replaces LS-C90949
Antibody:
Rabbit Polyclonal to Human GPRC5A / RAI3
Application:
IHC, IHC-P
Reactivity:
Human, Monkey
Format:
Unconjugated, Unmodified
Other formats:
Price
Catalog Number
$425 
LS-A3552-50
50 µg
1 mg/ml

Toll Free North America
866-819-4732

Overview

Antibody:
Rabbit Polyclonal to Human GPRC5A / RAI3
Application:
IHC, IHC-P
Reactivity:
Human, Monkey
Format:
Unconjugated, Unmodified
Other formats:

Specifications

Description
GPRC5A plays a role in regulating differentiation and in maintaining homeostasis of epithelial cells, exerting its effects via multiple signaling pathways including cAMP, NF-kB, FAK/Src and STAT3. It is also thought to be involved in the embryonic development and maturation of the lung and kidneys. It is expressed in epithelial cells in the adult lung, where it is involved in negative regulation of STAT3. Deletion of GPRC5A leads to spontaneous tumorigenesis in the lung in mice, and it has suppressed expression in non-small cell lung cancer cell lines, suggesting a role as a tumor suppressor (likely via its regulation of STAT3) in the lung. In some other cancers, GPRC5A seems to promote tumorigenesis and elevated levels are associated with poor prognosis in colorectal cancer, gastric cancer, and pancreatic carcinoma. In immunohistochemistry, GPRC5A has highest membranous positivity int he lung, and is also found in the kidney, gastrointestinal tissue, thyroid, brain, and at lower levels in a few other tissues. References: Cancer Res. 2010 Nov 1;70(21):8917-26, PMID: 20959490; BioMed Research International. 2018. 2018 (1823726), DOI: 10.1155/2018/1823726
Target
Human GPRC5A / RAI3
Synonyms
GPRC5A | RAIG-1 | Retinoic acid induced 3 | Retinoic acid responsive | GPCR5A | RAI3 | RAIG1 | Retinoic acid-inducible gene 1
Host
Rabbit
Reactivity
Human, Monkey (tested or 100% immunogen sequence identity)
Predicted
Dog, Rabbit (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (16 - 17 µg/ml)
  • Applications tested for the base form of this product only
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
Synthetic 15 amino acid peptide from 3rd transmembrane domain of human GPRC5A / RAI3. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset (100%); Panda, Dog, Rabbit (93%); Mouse, Hamster, Bovine (87%); Elephant, Horse (80%).
Blocking Peptide
LS-E28776 - Liquid - 50 µg - $145.00
Immunizing peptide used to generate LS-A3552. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
Epitope
Transmembrane Domain
Specificity
Human GPRC5A / RAI3. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About GPRC5A / RAI3
Q8NFJ5 NM_003979 NP_003970.1

Validation

GPRC5A / RAI3 Antibody - Colon, Carcinoma
Colon, Carcinoma
Colon, Carcinoma

GPRC5A / RAI3 Antibody - Breast carcinoma
Breast carcinoma
Breast carcinoma

GPRC5A / RAI3 Antibody - Ovary, Carcinoma
Ovary, Carcinoma
Ovary, Carcinoma

GPRC5A / RAI3 Antibody - Lung, Non Small-Cell Carcinoma
Lung, Non Small-Cell Carcinoma
Lung, Non Small-Cell Carcinoma

GPRC5A / RAI3 Antibody - Anti-GPRC5A / RAI3 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPRC5A / RAI3 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPRC5A / RAI3 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

GPRC5A / RAI3 Antibody - Anti-GPRC5A / RAI3 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPRC5A / RAI3 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPRC5A / RAI3 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

GPRC5A / RAI3 Antibody - Anti-GPRC5A / RAI3 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPRC5A / RAI3 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPRC5A / RAI3 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

GPRC5A / RAI3 Antibody - Anti-GPRC5A / RAI3 antibody IHC of human Pancreas, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPRC5A / RAI3 antibody IHC of human Pancreas, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPRC5A / RAI3 antibody IHC of human Pancreas, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

GPRC5A / RAI3 Antibody - Breast, Carcinoma
Breast, Carcinoma
Breast, Carcinoma

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Requested From: United States
Date Requested: 2/25/2020