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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Cell Cycle Pathways
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Catalog Number Size Price
LS-A1193-50 50 µg (1 mg/ml) $425 
GPR68 / OGR1 Antibody - Lymph node, Hodgkin's lymphoma, Reed Sternberg cells
GPR68 / OGR1 Antibody - Brain, Substantia Nigra
GPR68 / OGR1 Antibody - Colon, Adenocarcinoma
GPR68 / OGR1 Antibody - Lymph node, Hodgkin's lymphoma, Reed Sternberg cells
GPR68 / OGR1 Antibody - Brain, Substantia Nigra
GPR68 / OGR1 Antibody - Colon, Adenocarcinoma
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PathPlus™ GPR68 / OGR1 Antibody Extracellular Domain Polyclonal IHC LS‑A1193

PathPlus™ GPR68 / OGR1 Antibody Extracellular Domain Polyclonal IHC LS‑A1193

Note: This antibody replaces LS-C67014
Antibody:
Rabbit Polyclonal to Human GPR68 / OGR1
Application:
IHC, IHC-P
Reactivity:
Human, Rat
Format:
Unconjugated, Unmodified
Other formats:
Price
Catalog Number
$425 
LS-A1193-50
50 µg
1 mg/ml
Toll Free North America
866-819-4732

Overview

Antibody:
Rabbit Polyclonal to Human GPR68 / OGR1
Application:
IHC, IHC-P
Reactivity:
Human, Rat
Format:
Unconjugated, Unmodified
Other formats:

Specifications

Description
G protein-coupled receptor 68 (GPR68) is a proton-sensing receptor involved in pH homeostasis. GPR68 represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. GPR68 mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca2+ mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. GPR68 also functions as a metastasis suppressor in prostate cancer. The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804
Target
Human GPR68 / OGR1
Host
Rabbit
Reactivity
Human, Rat (tested or 100% immunogen sequence identity)
Predicted
Monkey (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (1.25 µg/ml)
  • Applications tested for the base form of this product only
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
Synthetic 16 amino acid peptide from 2nd extracellular domain of human GPR68. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon (100%); Monkey, Marmoset (94%); Horse (88%).
Blocking Peptide
LS-E28169 - Liquid - 50 µg - $145.00
Immunizing peptide used to generate LS-A1193. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
Epitope
Extracellular Domain
Specificity
Human GPR68. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About GPR68 / OGR1
Q15743 NM_003485 NP_003476.3

Validation

GPR68 / OGR1 Antibody - Lymph node, Hodgkin's lymphoma, Reed Sternberg cells
Lymph node, Hodgkin's lymphoma, Reed Sternberg cells
Lymph node, Hodgkin's lymphoma, Reed Sternberg cells

GPR68 / OGR1 Antibody - Brain, Substantia Nigra
Brain, Substantia Nigra
Brain, Substantia Nigra

GPR68 / OGR1 Antibody - Colon, Adenocarcinoma
Colon, Adenocarcinoma
Colon, Adenocarcinoma

Publications (1)

Convergent signaling by acidosis and receptor activator of NF-kappaB ligand (RANKL) on the calcium/calcineurin/NFAT pathway in osteoclasts. Komarova SV, Pereverzev A, Shum JW, Sims SM and Dixon SJ. Proceedings of the National Academy of Sciences of the United States of America. 2005 102:2643-8. (Rat)

Customer Reviews (0)


Requested From: United States
Date Requested: 11/18/2019