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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Cell Cycle Pathways
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Catalog Number Size Price
LS-A1194-50 50 µg (1 mg/ml) $425 
GPR68 / OGR1 Antibody - Colon, Adenocarcinoma
GPR68 / OGR1 Antibody - Brain, glioblastoma
GPR68 / OGR1 Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
GPR68 / OGR1 Antibody - Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
GPR68 / OGR1 Antibody - Colon, Adenocarcinoma
GPR68 / OGR1 Antibody - Brain, glioblastoma
GPR68 / OGR1 Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
GPR68 / OGR1 Antibody - Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
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PathPlus™ Polyclonal Rabbit anti‑Human GPR68 / OGR1 Antibody (C‑Terminus, IHC, IF) LS‑A1194

PathPlus™ Polyclonal Rabbit anti‑Human GPR68 / OGR1 Antibody (C‑Terminus, IHC, IF) LS‑A1194

Antibody:
Rabbit Polyclonal to Human GPR68 / OGR1
Application:
IHC, IHC-P, ICC, IF
Reactivity:
Human, Monkey, Mouse, Rat, Bovine, Hamster, Horse, Pig, Rabbit
Format:
Unconjugated, Unmodified
Other formats:
Price
Catalog Number
$425 
LS-A1194-50
50 µg
1 mg/ml

Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
Rabbit Polyclonal to Human GPR68 / OGR1
Application:
IHC, IHC-P, ICC, IF
Reactivity:
Human, Monkey, Mouse, Rat, Bovine, Hamster, Horse, Pig, Rabbit
Format:
Unconjugated, Unmodified
Other formats:

Specifications

Description
G protein-coupled receptor 68 (GPR68) is a proton-sensing receptor involved in pH homeostasis. GPR68 represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. GPR68 mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca2+ mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. GPR68 also functions as a metastasis suppressor in prostate cancer. References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804
Target
Human GPR68 / OGR1
Synonyms
GPR68 | Brgrb | G protein-coupled receptor 68 | G-protein coupled receptor 68 | OGR1 | Brgr1 | GPR12A | OGR-1
Host
Rabbit
Reactivity
Human, Monkey, Mouse, Rat, Bovine, Hamster, Horse, Pig, Rabbit (tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (10 - 20 µg/ml)
  • ICC
  • Immunofluorescence
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Failed Applications
  • IHC - Paraffin
Immunogen
Synthetic 16 amino acid peptide from C-Terminus of human GPR68. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Bovine, Hamster, Elephant, Horse, Rabbit, Pig (100%); Dog, Bat, Panda, Platypus (88%).
Blocking Peptide
LS-E28170 - Liquid - 50 µg 1 mg/ml - $145.00
Immunizing peptide used to generate LS-A1194. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
Epitope
C-Terminus
Specificity
Human GPR68. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About GPR68 / OGR1
Q15743 NM_003485 NP_003476.3

Validation

GPR68 / OGR1 Antibody - Colon, Adenocarcinoma
Colon, Adenocarcinoma
Colon, Adenocarcinoma

GPR68 / OGR1 Antibody - Brain, glioblastoma
Brain, glioblastoma
Brain, glioblastoma

GPR68 / OGR1 Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)

GPR68 / OGR1 Antibody - Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)

LSBio Ratings

PathPlus™ GPR68 / OGR1 Antibody (C-Terminus) for IHC, ICC, IF/Immunofluorescence LS-A1194 has an LSBio Rating of
Publications (4.3)
Laboratory Validation Score (5)

Publications (4)

Proton-sensing G-protein-coupled receptors. Ludwig MG, Vanek M, Guerini D, Gasser JA, Jones CE, Junker U, Hofstetter H, Wolf RM, Seuwen K. Nature. 2003 425:93-8. (IHC; Rat)

Convergent signaling by acidosis and receptor activator of NF-kappaB ligand (RANKL) on the calcium/calcineurin/NFAT pathway in osteoclasts. Komarova SV, Pereverzev A, Shum JW, Sims SM and Dixon SJ. Proceedings of the National Academy of Sciences of the United States of America. 2005 102:2643-8. (Rat)

Expression of and role for ovarian cancer G-protein coupled receptor 1 (OGR1) during osteoclastogenesis. Yang M, Mailhot G, Birnbaum MJ, Mackay CA, Mason-Savas A and Odgren PR. The Journal of biological chemistry. 2006 281:23598-605. (ICC; Rat)

Mutations in the pH-Sensing G-protein-Coupled Receptor GPR68 Cause Amelogenesis Imperfecta. Parry DA, Smith CE, El-Sayed W, Poulter JA, Shore RC, Logan CV, Mogi C, Sato K, Okajima F, Harada A, Zhang H, Koruyucu M, Seymen F, Hu JC, Simmer JP, Ahmed M, Jafri H, Johnson CA, Inglehearn CF, Mighell AJ. American journal of human genetics. 2016 October;99:984-990. (Human)

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Requested From: United States
Date Requested: 6/6/2020