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| Catalog Number | Size | Price |
|---|---|---|
| LS-A1194-50 | 50 µg (1 mg/ml) | $440 |
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PathPlus™ Polyclonal Rabbit anti‑Human GPR68 / OGR1 Antibody (C‑Terminus, IHC) LS‑A1194
PathPlus™ Polyclonal Rabbit anti‑Human GPR68 / OGR1 Antibody (C‑Terminus, IHC) LS‑A1194
Antibody:
GPR68 / OGR1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Application:
IHC-P
Reactivity:
Human, Monkey, Mouse, Rat, Bovine, Hamster, Horse, Pig, Rabbit
Format:
Unconjugated, Unmodified
Overview
Antibody:
GPR68 / OGR1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Application:
IHC-P
Reactivity:
Human, Monkey, Mouse, Rat, Bovine, Hamster, Horse, Pig, Rabbit
Format:
Unconjugated, Unmodified
Specifications
Description
G protein-coupled receptor 68 (GPR68) is a proton-sensing receptor involved in pH homeostasis. GPR68 represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. GPR68 mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca2+ mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. GPR68 also functions as a metastasis suppressor in prostate cancer.
References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804
Target
Human GPR68 / OGR1
Synonyms
GPR68 | Brgrb | G protein-coupled receptor 68 | G-protein coupled receptor 68 | OGR1 | Brgr1 | GPR12A | OGR-1
Host
Rabbit
Reactivity
Human, Monkey, Mouse, Rat, Bovine, Hamster, Horse, Pig, Rabbit
(tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Synthetic 16 amino acid peptide from C-Terminus of human GPR68. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Bovine, Hamster, Elephant, Horse, Rabbit, Pig (100%); Dog, Bat, Panda, Platypus (88%).
Epitope
C-Terminus
Specificity
Human GPR68. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Applications
- IHC - Paraffin (10 - 20 µg/ml)
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About GPR68 / OGR1
Validation
Colon, Adenocarcinoma
Colon, Adenocarcinoma
Brain, glioblastoma
Brain, glioblastoma
Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
See More About...
LSBio Ratings
PathPlus™ GPR68 / OGR1 Antibody (C-Terminus) for IHC LS-A1194 has an LSBio Rating of
Publications (4.3)
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
Publications (4)
Proton-sensing G-protein-coupled receptors. Ludwig MG, Vanek M, Guerini D, Gasser JA, Jones CE, Junker U, Hofstetter H, Wolf RM, Seuwen K. Nature. 2003 425:93-8. (IHC; Rat)
Convergent signaling by acidosis and receptor activator of NF-kappaB ligand (RANKL) on the calcium/calcineurin/NFAT pathway in osteoclasts. Komarova SV, Pereverzev A, Shum JW, Sims SM and Dixon SJ. Proceedings of the National Academy of Sciences of the United States of America. 2005 102:2643-8. (Rat)
Expression of and role for ovarian cancer G-protein coupled receptor 1 (OGR1) during osteoclastogenesis. Yang M, Mailhot G, Birnbaum MJ, Mackay CA, Mason-Savas A and Odgren PR. The Journal of biological chemistry. 2006 281:23598-605. (ICC; Rat)
Mutations in the pH-Sensing G-protein-Coupled Receptor GPR68 Cause Amelogenesis Imperfecta. Parry DA, Smith CE, El-Sayed W, Poulter JA, Shore RC, Logan CV, Mogi C, Sato K, Okajima F, Harada A, Zhang H, Koruyucu M, Seymen F, Hu JC, Simmer JP, Ahmed M, Jafri H, Johnson CA, Inglehearn CF, Mighell AJ. American journal of human genetics. 2016 October;99:984-990. (Human)
Customer Reviews (0)
Featured Products
Species:
Human
Applications:
IHC, IHC - Paraffin, ICC, ELISA
Species:
Human, Bat, Horse
Applications:
IHC, IHC - Paraffin, ELISA
Species:
Human, Monkey, Rat
Applications:
IHC, IHC - Paraffin, ELISA
Species:
Human, Monkey, Mouse, Rat, Bovine, Dog, Hamster, Horse, Pig, Rabbit
Applications:
IHC, IHC - Paraffin
Species:
Human, Monkey, Mouse, Rat, Bat, Hamster, Horse, Pig, Rabbit
Applications:
IHC, IHC - Paraffin
Reactivity:
Human, Mouse
Range:
Positive/Negative
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 4/19/2024
Date Requested: 4/19/2024
