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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Catalog Number Size Price
LS-A2719-50 50 µg (1 mg/ml) $425 
GPR139 Antibody - Prostate, Carcinoma
GPR139 Antibody - Lung, Adenocarcinoma
GPR139 Antibody - Breast, carcinoma
GPR139 Antibody - Anti-GPR139 antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
GPR139 Antibody - Anti-GPR139 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
GPR139 Antibody - Prostate, Carcinoma
GPR139 Antibody - Lung, Adenocarcinoma
GPR139 Antibody - Breast, carcinoma
GPR139 Antibody - Anti-GPR139 antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
GPR139 Antibody - Anti-GPR139 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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PathPlus™ Polyclonal GPR139 Antibody (Transmembrane Domain, IHC) LS‑A2719

PathPlus™ Polyclonal GPR139 Antibody (Transmembrane Domain, IHC) LS‑A2719

Antibody:
Rabbit Polyclonal to Human GPR139
Application:
IHC, IHC-P
Reactivity:
Human, Monkey, Mouse, Rat, Dog, Hamster, Horse, Pig, Rabbit
Format:
Unconjugated, Unmodified
Other formats:
Price
Catalog Number
$425 
LS-A2719-50
50 µg
1 mg/ml

Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
Rabbit Polyclonal to Human GPR139
Application:
IHC, IHC-P
Reactivity:
Human, Monkey, Mouse, Rat, Dog, Hamster, Horse, Pig, Rabbit
Format:
Unconjugated, Unmodified
Other formats:

Specifications

Description
GPR139 is a G protein-coupled receptor thought to act on the Gq/11 pathway and whose endogenous agonists are thought to be L-Trp and L-Phe (aromatic amino acids) and also ACTH/alpha-MSH-related peptides. It has putative functions in regulating locomotion, metabolism and addiction and may be relevant to dysfunction of these processes in Parkinson's disease, diabetes and hyperalgesia. In immunohistochemistry, GPR139 has membranous positivity in the striatum, hypothalamus, pituitary, thalamus and habenula in the central nervous system and is nearly absent in peripheral tissues (endometrium and smooth muscle may stain). References: Basic Clin Pharmacol Toxicol. 2019;00:1–12, DOI: 10.1111/bcpt.13263; Neurochem Int. 2017 Jan; 102: 105–113, PMID: 27916541
Target
Human GPR139
Synonyms
GPR139 | G protein-coupled receptor 139 | PGR3 | GPRg1
Host
Rabbit
Reactivity
Human, Monkey, Mouse, Rat, Dog, Hamster, Horse, Pig, Rabbit (tested or 100% immunogen sequence identity)
Predicted
Bovine, Chicken (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (18 µg/ml)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
Synthetic 16 amino acid peptide from 4th transmembrane domain of human GPR139. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Hamster, Elephant, Panda, Dog, Horse, Rabbit, Pig (100%); Bovine, Opossum, Turkey, Chicken, Platypus (94%).
Blocking Peptide
LS-E28605 - Liquid - 50 µg - $145.00
Immunizing peptide used to generate LS-A2719. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
Epitope
Transmembrane Domain
Specificity
Human GPR139. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except GPR142 (50%).
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About GPR139
Q6DWJ6 AJ303165 CAC33085.1

Validation

GPR139 Antibody - Prostate, Carcinoma
Prostate, Carcinoma
Prostate, Carcinoma

GPR139 Antibody - Lung, Adenocarcinoma
Lung, Adenocarcinoma
Lung, Adenocarcinoma

GPR139 Antibody - Breast, carcinoma
Breast, carcinoma
Breast, carcinoma

GPR139 Antibody - Anti-GPR139 antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPR139 antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPR139 antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

GPR139 Antibody - Anti-GPR139 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPR139 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPR139 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

LSBio Ratings

PathPlus™ GPR139 Antibody (Transmembrane Domain) for IHC LS-A2719 has an LSBio Rating of
Laboratory Validation Score (5)

Publications (0)

Customer Reviews (0)


Requested From: United States
Date Requested: 4/7/2020