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| Catalog Number | Size | Price |
|---|---|---|
| LS-A1312-50 | 50 µg (1 mg/ml) | $440 |
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2 of 3
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PathPlus™ Polyclonal Rabbit anti‑Human GLP2R Antibody (N‑Terminus, IHC, IF, WB) LS‑A1312
PathPlus™ Polyclonal Rabbit anti‑Human GLP2R Antibody (N‑Terminus, IHC, IF, WB) LS‑A1312
Antibody:
GLP2R Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Application:
IHC, IHC-P, ICC, IF, WB, IP
Reactivity:
Human, Monkey, Guinea pig
Format:
Unconjugated, Unmodified
Overview
Antibody:
GLP2R Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Application:
IHC, IHC-P, ICC, IF, WB, IP
Reactivity:
Human, Monkey, Guinea pig
Format:
Unconjugated, Unmodified
Specifications
Description
Glucagon-like peptide 2 receptor (GLP2R) is closely related to the Glucagon Receptor and to the GLP1 Receptor. The glucagon-like peptides (GLP-1 and GLP-2) are proglucagon-derived peptides cosecreted from gut endocrine cells in response to nutrient ingestion. GLP2R is mediated by the GLP-2 receptor expressed on subsets of enteric nerves and enteroendocrine cells in the stomach and small and large intestine. Activation of GLP2R signaling promotes expansion of the mucosal epithelium indirectly via activation of growth and anti-apoptotic pathways. GLP2R, through its ligand glucagon-like peptide 2 (GLP2), has been shown to prevent intestinal hypoplasia resulting from total parenteral nutrition.
References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804
Target
Human GLP2R
Synonyms
GLP2R | GLP-2-R | GLP-2 receptor | GLP-2R | Glp2 receptor
Host
Rabbit
Reactivity
Human, Monkey, Guinea pig
(tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Synthetic 18 amino acid peptide from N-Terminus extracellular domain of human GLP2R. Percent identity with other species by BLAST analysis: Human, Gorilla, Monkey, Marmoset (100%); Gibbon (94%); Bovine, Dog, Elephant, Panda, Pig (89%); Bat, Rabbit (83%).
Epitope
N-Terminus
Specificity
Human GLP2R. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Applications
- IHC
- IHC - Paraffin (10 - 20 µg/ml)
- ICC
- Immunofluorescence
- Western blot
- Immunoprecipitation
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About GLP2R
Validation
Anti-GLP2R antibody IHC of human small intestine, neuroendocrine cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GLP2R antibody IHC of human small intestine, neuroendocrine cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Brain, Alzheimer's disease senile plaque
Brain, Alzheimer's disease senile plaque
Brain, hippocampus CA2
Brain, hippocampus CA2
See More About...
LSBio Ratings
PathPlus™ GLP2R Antibody (N-Terminus) for IHC, ICC, IF/Immunofluorescence, WB/Western, IP LS-A1312 has an LSBio Rating of
Publications (4.5)
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
Publications (6)
GLP-2 receptor localizes to enteric neurons and endocrine cells expressing vasoactive peptides and mediates increased blood flow. Guan X, Karpen HE, Stephens J, Bukowski JT, Niu S, Zhang G, Stoll B, Finegold MJ, Holst JJ, Hadsell D, Hadsell DL, Nichols BL, Burrin DG. Gastroenterology. 2006 130:150-64. (ICC, WB, IHC-P, Compet; Monkey, Pig)
Glucagon-like peptide-2 modulates neurally evoked mucosal chloride secretion in guinea pig small intestine in vitro. Baldassano S, Liu S, Qu MH, Mul F, Wood JD. American journal of physiology. Gastrointestinal and liver physiology. 2009 297:G800-5. (IHC; Guinea pig)
Acute effects of the glucagon-like peptide 2 analogue, teduglutide, on intestinal adaptation in short bowel syndrome. Thymann T, Stoll B, Mecklenburg L, Burrin DG, Vegge A, Qvist N, Eriksen T, Jeppesen PB, Sangild PT. Journal of pediatric gastroenterology and nutrition. 2014 Jun;58:694-702.
Glugacon-like peptide-2: broad receptor expression, limited therapeutic effect on intestinal inflammation and novel role in liver regeneration. El-Jamal N, Erdual E, Neunlist M, Koriche D, Dubuquoy C, Maggiotto F, Chevalier J, Berrebi D, Dubuquoy L, Boulanger E, Cortot A, Desreumaux P. American journal of physiology. Gastrointestinal and liver physiology. Aug;307:G274-85.
Influence of Cane Molasses Inclusion to Dairy Cow Diets during the Transition Period on Rumen Epithelial Development. William F Miller, Evan C Titgemeyer, Tiruvoor G Nagaraja, Daniel H M Watanabe, Luana D Felizari, Danilo D Millen, Zachary K Smith, Bradley J Johnson. Animals: an open access journal from MDPI. 2021 April;11:
GLP-2 Is Locally Produced From Human Islets and Balances Inflammation Through an Inter-Islet-Immune Cell Crosstalk. Wei He, Osmond D Rebello, Antonia Henne, Fabian Nikolka, Thomas Klein, Kathrin Maedler. Frontiers in endocrinology. 2021 July;12:697120.
Customer Reviews (0)
Featured Products
Species:
Human, Monkey
Applications:
IHC, IHC - Paraffin
Species:
Human, Monkey
Applications:
IHC, IHC - Paraffin
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 4/19/2024
Date Requested: 4/19/2024
