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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Catalog Number Size Price
LS-A4273-50 50 µg (1 mg/ml) $425 
FZD5 / Frizzled 5 Antibody - Non-Hodgkin's lymphoma
FZD5 / Frizzled 5 Antibody - Colon, Carcinoma
FZD5 / Frizzled 5 Antibody - Lung, non small-cell carcinoma
FZD5 / Frizzled 5 Antibody - Anti-FZD5 / Frizzled 5 antibody IHC of human Colon, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
FZD5 / Frizzled 5 Antibody - Anti-FZD5 / Frizzled 5 antibody IHC of human pancreas and carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
FZD5 / Frizzled 5 Antibody - Anti-FZD5 / Frizzled 5 antibody IHC of human synovium, rheumatoid arthritis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
FZD5 / Frizzled 5 Antibody - Non-Hodgkin's lymphoma
FZD5 / Frizzled 5 Antibody - Colon, Carcinoma
FZD5 / Frizzled 5 Antibody - Lung, non small-cell carcinoma
FZD5 / Frizzled 5 Antibody - Anti-FZD5 / Frizzled 5 antibody IHC of human Colon, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
FZD5 / Frizzled 5 Antibody - Anti-FZD5 / Frizzled 5 antibody IHC of human pancreas and carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
FZD5 / Frizzled 5 Antibody - Anti-FZD5 / Frizzled 5 antibody IHC of human synovium, rheumatoid arthritis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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PathPlus™ Polyclonal Rabbit anti‑Human FZD5 / Frizzled 5 Antibody (N‑Terminus, IHC) LS‑A4273

PathPlus™ Polyclonal Rabbit anti‑Human FZD5 / Frizzled 5 Antibody (N‑Terminus, IHC) LS‑A4273

Antibody:
Rabbit Polyclonal to Human FZD5 / Frizzled 5
Application:
IHC, IHC-P
Reactivity:
Human, Mouse, Rat, Hamster
Format:
Unconjugated, Unmodified
Other formats:
Price
Catalog Number
$425 
LS-A4273-50
50 µg
1 mg/ml

Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
Rabbit Polyclonal to Human FZD5 / Frizzled 5
Application:
IHC, IHC-P
Reactivity:
Human, Mouse, Rat, Hamster
Format:
Unconjugated, Unmodified
Other formats:

Specifications

Description
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Interacts specifically with Wnt5A to induce the beta-catenin pathway. References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804
Target
Human FZD5 / Frizzled 5
Synonyms
FZD5 | C2orf31 | DKFZP434E2135 | Frizzled family receptor 5 | Fz5 | Fzd-5 | FzE5 | Frizzled 5 | Frizzled-5 | Wnt receptor | Fz-5 | HFZ5
Host
Rabbit
Reactivity
Human, Mouse, Rat, Hamster (tested or 100% immunogen sequence identity)
Predicted
Dog, Rabbit (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (19 µg/ml)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
Synthetic 16 amino acid peptide from N-Terminus extracellular domain of human FZD5 / Frizzled 5. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Mouse, Rat, Hamster, Elephant (100%); Dog, Rabbit (94%); Marmoset, Bovine, Pig (88%).
Blocking Peptide
LS-E28934 - Liquid - 50 µg 1 mg/ml - $145.00
Immunizing peptide used to generate LS-A4273. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
Epitope
N-Terminus
Specificity
Human FZD5 / Frizzled 5. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About FZD5 / Frizzled 5
Q13467 NM_003468 NP_003459.2

Validation

FZD5 / Frizzled 5 Antibody - Non-Hodgkin's lymphoma
Non-Hodgkin's lymphoma
Non-Hodgkin's lymphoma

FZD5 / Frizzled 5 Antibody - Colon, Carcinoma
Colon, Carcinoma
Colon, Carcinoma

FZD5 / Frizzled 5 Antibody - Lung, non small-cell carcinoma
Lung, non small-cell carcinoma
Lung, non small-cell carcinoma

FZD5 / Frizzled 5 Antibody - Anti-FZD5 / Frizzled 5 antibody IHC of human Colon, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-FZD5 / Frizzled 5 antibody IHC of human Colon, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-FZD5 / Frizzled 5 antibody IHC of human Colon, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

FZD5 / Frizzled 5 Antibody - Anti-FZD5 / Frizzled 5 antibody IHC of human pancreas and carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-FZD5 / Frizzled 5 antibody IHC of human pancreas and carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-FZD5 / Frizzled 5 antibody IHC of human pancreas and carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

FZD5 / Frizzled 5 Antibody - Anti-FZD5 / Frizzled 5 antibody IHC of human synovium, rheumatoid arthritis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-FZD5 / Frizzled 5 antibody IHC of human synovium, rheumatoid arthritis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-FZD5 / Frizzled 5 antibody IHC of human synovium, rheumatoid arthritis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

LSBio Ratings

PathPlus™ FZD5 / Frizzled 5 Antibody (N-Terminus) for IHC LS-A4273 has an LSBio Rating of
Publications (4)
Laboratory Validation Score (5)

Publications (1)

RAL GTPases Drive Intestinal Stem Cell Function and Regeneration through Internalization of WNT Signalosomes. Johansson J, Naszai M, Hodder MC, Pickering KA, Miller BW, Ridgway RA, Yu Y, Peschard P, Brachmann S, Campbell AD, Cordero JB, Sansom OJ. Cell stem cell. 2019 April;24:592-607.

Customer Reviews (0)


Requested From: United States
Date Requested: 7/11/2020