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Catalog Number Size Price
LS-A1049-50 50 µg (1 mg/ml) $425 
FP / PTGFR Antibody - Skin, Malignant Melanoma
FP / PTGFR Antibody - Breast, Carcinoma
FP / PTGFR Antibody - Skin, Malignant Melanoma
FP / PTGFR Antibody - Anti-PTGFR antibody IHC of human ovary. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
FP / PTGFR Antibody - Anti-PTGFR antibody immunocytochemistry (ICC) staining of HEK293 human embryonic kidney cells transfected with PTGFR.
FP / PTGFR Antibody - Anti-PTGFR antibody immunocytochemistry (ICC) staining of untransfected HEK293 human embryonic kidney cells.
FP / PTGFR Antibody - Skin, Malignant Melanoma
FP / PTGFR Antibody - Breast, Carcinoma
FP / PTGFR Antibody - Skin, Malignant Melanoma
FP / PTGFR Antibody - Anti-PTGFR antibody IHC of human ovary. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
FP / PTGFR Antibody - Anti-PTGFR antibody immunocytochemistry (ICC) staining of HEK293 human embryonic kidney cells transfected with PTGFR.
FP / PTGFR Antibody - Anti-PTGFR antibody immunocytochemistry (ICC) staining of untransfected HEK293 human embryonic kidney cells.
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PathPlus™ Polyclonal FP / PTGFR Antibody (Extracellular Domain, IHC) LS‑A1049

PathPlus™ Polyclonal FP / PTGFR Antibody (Extracellular Domain, IHC) LS‑A1049

Antibody:
Rabbit Polyclonal to Human FP / PTGFR
Application:
IHC, IHC-P, ICC
Reactivity:
Human, Monkey, Horse
Format:
Unconjugated, Unmodified
Other formats:
Price
Catalog Number
$425 
LS-A1049-50
50 µg
1 mg/ml

Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
Rabbit Polyclonal to Human FP / PTGFR
Application:
IHC, IHC-P, ICC
Reactivity:
Human, Monkey, Horse
Format:
Unconjugated, Unmodified
Other formats:

Specifications

Description
PTGFR is a receptor for prostaglandin F2-alpha (PGF2-alpha). PTGFR activity is mediated by G proteins that activate a phosphatidylinositol-calcium second messenger system. It has various functions in different tissues throughout the body, ranging from hair growth to reproductive signaling, hyperpigmentation of the skin, regulation of allergic response and inflammation, blood pressure control, and regulation of bone remodeling. In the corpus luteum, it initiates luteolysis. Studies in fish demonstrate that PTGFR and prostaglandin F2-alpha control the initiation of female sexual behaviour and regulate neural circuits involved with fertility status in the brain. Additionally, PTGFR is a target of agonists as part of treatment therapies for various diseases including glaucoma, hypotrichosis of the eyelashes, and periorbital vitiligo or hypopigmentation of the skin. In immunohistochemistry, PTGFR has membranous positivity in the uterine myometrium, in smooth muscle cells and the endothelium in the eye, as well as distal tubules of the kidney and luteal cells of the corpus luteum in the ovaries. References: Curr Biol. 2016 Apr 4;26(7):943-9, PMID: 26996507; American Academy of Dermatology. 2015. 72 (4): 712–6, PMID: 25601618; Prostaglandins & Other Lipid Mediators. 2013. 104–105: 109–21, PMID: 23353557;
Target
Human FP / PTGFR
Synonyms
PTGFR | PGF receptor | PGF2-alpha receptor | Prostaglandin F receptor (FP) | FP | PGF2 alpha receptor | Prostaglandin F receptor | Prostanoid FP receptor
Host
Rabbit
Reactivity
Human, Monkey, Horse (tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (4 - 8 µg/ml)
  • ICC
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
Synthetic 16 amino acid peptide from 2nd extracellular domain of human PTGFR. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Horse (100%); Mouse, Rat, Dog (88%); Sheep, Bovine, Hamster, Panda, Rabbit (81%).
Blocking Peptide
LS-E28113 - Liquid - 50 µg - $145.00
Immunizing peptide used to generate LS-A1049. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
Epitope
Extracellular Domain
Specificity
Human PTGFR. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About FP / PTGFR
P43088 NM_000959 NP_000950.1

Validation

FP / PTGFR Antibody - Skin, Malignant Melanoma
Skin, Malignant Melanoma
Skin, Malignant Melanoma

FP / PTGFR Antibody - Breast, Carcinoma
Breast, Carcinoma
Breast, Carcinoma

FP / PTGFR Antibody - Skin, Malignant Melanoma
Skin, Malignant Melanoma
Skin, Malignant Melanoma

FP / PTGFR Antibody - Anti-PTGFR antibody IHC of human ovary. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-PTGFR antibody IHC of human ovary. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-PTGFR antibody IHC of human ovary. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

FP / PTGFR Antibody - Anti-PTGFR antibody immunocytochemistry (ICC) staining of HEK293 human embryonic kidney cells transfected with PTGFR.
Anti-PTGFR antibody immunocytochemistry (ICC) staining of HEK293 human embryonic kidney cells transfected with PTGFR.
Anti-PTGFR antibody immunocytochemistry (ICC) staining of HEK293 human embryonic kidney cells transfected with PTGFR.

FP / PTGFR Antibody - Anti-PTGFR antibody immunocytochemistry (ICC) staining of untransfected HEK293 human embryonic kidney cells.
Anti-PTGFR antibody immunocytochemistry (ICC) staining of untransfected HEK293 human embryonic kidney cells.
Anti-PTGFR antibody immunocytochemistry (ICC) staining of untransfected HEK293 human embryonic kidney cells.

LSBio Ratings

PathPlus™ FP / PTGFR Antibody (Extracellular Domain) for IHC, ICC LS-A1049 has an LSBio Rating of
Laboratory Validation Score (5)

Publications (0)

Customer Reviews (0)


Requested From: United States
Date Requested: 4/3/2020