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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Catalog Number Size Price
LS-A261-50 50 µg (0.65 mg/ml) $425 
F2RL2 / PAR3 Antibody - Colon, Carcinoma
F2RL2 / PAR3 Antibody - Pancreas, carcinoma
F2RL2 / PAR3 Antibody - Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE)
F2RL2 / PAR3 Antibody - Breast, Carcinoma
F2RL2 / PAR3 Antibody - Colon, Carcinoma
F2RL2 / PAR3 Antibody - Pancreas, carcinoma
F2RL2 / PAR3 Antibody - Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE)
F2RL2 / PAR3 Antibody - Breast, Carcinoma
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PathPlus™ Polyclonal F2RL2 / PAR3 Antibody (C‑Terminus, IHC) LS‑A261

PathPlus™ Polyclonal F2RL2 / PAR3 Antibody (C‑Terminus, IHC) LS‑A261

Antibody:
Rabbit Polyclonal to Human F2RL2 / PAR3
Application:
IHC, IHC-P, ICC
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:
Price
Catalog Number
$425 
LS-A261-50
50 µg
0.65 mg/ml

Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
Rabbit Polyclonal to Human F2RL2 / PAR3
Application:
IHC, IHC-P, ICC
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:

Specifications

Description
F2RL2 (PAR3) is a member of the protease-activated receptor (PAR) family of G protein-coupled cell surface receptors. F2RL2 is a cofactor in the thrombin-mediated cleavage and activation of the protease-activated receptor family member PAR4. It is essential for hemostasis and thrombosis, and is involved in inflammation and chronic inflammatory diseases. Cathepsin G activation of platelets is also dependent on F2RL2. In immunohistochemistry, F2RL2 has highest membranous positivity on megakaryocytes in bone marrow (with lower positivity in mature megakaryocytes), on patelets, and in other tissues including the heart, gut, retina and brain. References: Thrombosis J 17, 4 (2019). DOI:10.1186/s12959-019-0194-8
Target
Human F2RL2 / PAR3
Synonyms
F2RL2 | PAR-3 | Thrombin receptor-like 2 | PAR3 | Protease-activated receptor 3
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Predicted
Monkey (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (5 - 10 µg/ml)
  • ICC
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Failed Applications
  • Western blot
Immunogen
Synthetic 14 amino acid peptide from C-Terminus of human F2RL2. Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Gibbon, Monkey (93%); Marmoset (86%).
Blocking Peptide
LS-E35702 - Liquid - 50 µg - $145.00
Immunizing peptide used to generate LS-A261. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
Epitope
C-Terminus
Specificity
Human F2RL2. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About F2RL2 / PAR3
O00254 NM_004101 NP_004092.1

Validation

F2RL2 / PAR3 Antibody - Colon, Carcinoma
Colon, Carcinoma
Colon, Carcinoma

F2RL2 / PAR3 Antibody - Pancreas, carcinoma
Pancreas, carcinoma
Pancreas, carcinoma

F2RL2 / PAR3 Antibody - Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE)

F2RL2 / PAR3 Antibody - Breast, Carcinoma
Breast, Carcinoma
Breast, Carcinoma

LSBio Ratings

PathPlus™ F2RL2 / PAR3 Antibody (C-Terminus) for IHC, ICC LS-A261 has an LSBio Rating of
Laboratory Validation Score (5)

Publications (0)

Customer Reviews (0)


Requested From: United States
Date Requested: 4/3/2020