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Catalog Number Size Price
LS-A255-50 50 µg (1 mg/ml) $425 
F2RL1 / PAR2 Antibody - Breast, Carcinoma
F2RL1 / PAR2 Antibody - Brain, Glioblastoma
F2RL1 / PAR2 Antibody - Lung, adenocarcinoma
F2RL1 / PAR2 Antibody - Prostate, Carcinoma
F2RL1 / PAR2 Antibody - Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
F2RL1 / PAR2 Antibody - Anti-F2RL1 / PAR2 antibody IHC of human Breast, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
F2RL1 / PAR2 Antibody - Anti-F2RL1 / PAR2 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
F2RL1 / PAR2 Antibody - Human, Vascular smooth muscle: Formalin-Fixed Paraffin-Embedded (FFPE)
F2RL1 / PAR2 Antibody - Anti-F2RL1 / PAR2 antibody IHC of human Breast, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
F2RL1 / PAR2 Antibody - Breast, Carcinoma
F2RL1 / PAR2 Antibody - Brain, Glioblastoma
F2RL1 / PAR2 Antibody - Lung, adenocarcinoma
F2RL1 / PAR2 Antibody - Prostate, Carcinoma
F2RL1 / PAR2 Antibody - Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
F2RL1 / PAR2 Antibody - Anti-F2RL1 / PAR2 antibody IHC of human Breast, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
F2RL1 / PAR2 Antibody - Anti-F2RL1 / PAR2 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
F2RL1 / PAR2 Antibody - Human, Vascular smooth muscle: Formalin-Fixed Paraffin-Embedded (FFPE)
F2RL1 / PAR2 Antibody - Anti-F2RL1 / PAR2 antibody IHC of human Breast, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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PathPlus™ Polyclonal Rabbit anti‑Human F2RL1 / PAR2 Antibody (C‑Terminus, IHC) LS‑A255

PathPlus™ Polyclonal Rabbit anti‑Human F2RL1 / PAR2 Antibody (C‑Terminus, IHC) LS‑A255

Antibody:
Rabbit Polyclonal to Human F2RL1 / PAR2
Application:
IHC, IHC-P
Reactivity:
Human, Monkey
Format:
Unconjugated, Unmodified
Other formats:
Price
Catalog Number
$425 
LS-A255-50
50 µg
1 mg/ml

Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
Rabbit Polyclonal to Human F2RL1 / PAR2
Application:
IHC, IHC-P
Reactivity:
Human, Monkey
Format:
Unconjugated, Unmodified
Other formats:

Specifications

Description
Receptor for trypsin and trypsin-like enzymes coupled to G proteins. Its function is mediated through the activation of several signaling pathways including phospholipase C (PLC), intracellular calcium, mitogen-activated protein kinase (MAPK), I-kappaB kinase/NF-kappaB and Rho. Can also be transactivated by cleaved F2R/PAR1. Involved in modulation of inflammatory responses and regulation of innate and adaptive immunity, and acts as a sensor for proteolytic enzymes generated during infection. Generally is promoting inflammation. Can signal synergistically with TLR4 and probably TLR2 in inflammatory responses and modulates TLR3 signaling. Has a protective role in establishing the endothelial barrier; the activity involves coagulation factor X. Proposed to have a bronchoprotective role in airway epithelium, but also shown to compromise the airway epithelial barrier by interrupting E-cadherin adhesion. Involved in the regulation of vascular tone; activation results in hypotension presumably mediated by vasodilation. Associates with a subset of G proteins alpha subunits such as G alpha-q, G alpha-11, G alpha-14, G alpha-12 and G alpha-13, but probably not with G(o) alpha, G(i) subunit alpha-1 and G(i) subunit alpha-2. However, according to PubMed:21627585 can signal through G(i) subunit alpha. Believed to be a class B receptor which internalizes as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptor, for extended periods of time. Mediates inhibition of TNF-alpha stimulated JNK phosphorylation via coupling to G alpha-q/11; the function involves dissociation of RIPK1 and TRADD from TNFR1. Mediates phosphorylation of nuclear factor NF-kappa-B RELA subunit at 'Ser-536'; the function involves IKBKB and is predominantly independent of G proteins. Involved in cellular migration. Involved in cytoskeletal rearrangement and chemotaxis through beta-arrestin-promoted scaffolds; the function is independent of G alpha-q/11 and involves promotion of cofilin dephosphoryltaion and actin filament severing. Induces redistribution of COPS5 from the plasma membrane to the cytosol and activation of the JNK cascade is mediated by COPS5. Involved in the recruitment of leukocytes to the sites of inflammation and is the major PAR receptor capable of modulating eosinophil function such as proinflammatory cytokine secretion, superoxide production and degranulation. During inflammation promotes dendritic cell maturation, trafficking to the lymph nodes and subsequent T-cell activation. Involved in antimicrobial response of innate immnune cells; activation enhances phagocytosis of Gram-positive and killing of Gram-negative bacteria. Acts synergistically with interferon-gamma in enhancing antiviral responses. Implicated in a number of acute and chronic inflammatory diseases such as of the joints, lungs, brain, gastrointestinal tract, periodontium, skin, and vascular systems, and in autoimmune disorders. References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804
Target
Human F2RL1 / PAR2
Synonyms
F2RL1 | PAR2 | Thrombin receptor-like 1 | Protease-activated receptor 2 | G-protein coupled receptor 11 | GPR11 | PAR-2
Host
Rabbit
Reactivity
Human, Monkey (tested or 100% immunogen sequence identity)
Predicted
Bovine, Hamster, Rabbit (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (5 - 10 µg/ml)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
Synthetic 18 amino acid peptide from C-Terminus of human F2RL1. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey (100%); Bovine, Hamster, Rabbit (94%); Marmoset, Elephant, Panda, Pig, Opossum (89%); Mouse, Dog (83%).
Blocking Peptide
LS-E28567 - Liquid - 50 µg 1 mg/ml - $145.00
Immunizing peptide used to generate LS-A255. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
Epitope
C-Terminus
Specificity
Human F2RL1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About F2RL1 / PAR2
P55085 NM_005242 NP_005233.3

Validation

F2RL1 / PAR2 Antibody - Breast, Carcinoma
Breast, Carcinoma
Breast, Carcinoma

F2RL1 / PAR2 Antibody - Brain, Glioblastoma
Brain, Glioblastoma
Brain, Glioblastoma

F2RL1 / PAR2 Antibody - Lung, adenocarcinoma
Lung, adenocarcinoma
Lung, adenocarcinoma

F2RL1 / PAR2 Antibody - Prostate, Carcinoma
Prostate, Carcinoma
Prostate, Carcinoma

F2RL1 / PAR2 Antibody - Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)

F2RL1 / PAR2 Antibody - Anti-F2RL1 / PAR2 antibody IHC of human Breast, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-F2RL1 / PAR2 antibody IHC of human Breast, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-F2RL1 / PAR2 antibody IHC of human Breast, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

F2RL1 / PAR2 Antibody - Anti-F2RL1 / PAR2 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-F2RL1 / PAR2 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-F2RL1 / PAR2 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

F2RL1 / PAR2 Antibody - Human, Vascular smooth muscle: Formalin-Fixed Paraffin-Embedded (FFPE)
Human, Vascular smooth muscle: Formalin-Fixed Paraffin-Embedded (FFPE)
Human, Vascular smooth muscle: Formalin-Fixed Paraffin-Embedded (FFPE)

F2RL1 / PAR2 Antibody - Anti-F2RL1 / PAR2 antibody IHC of human Breast, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-F2RL1 / PAR2 antibody IHC of human Breast, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-F2RL1 / PAR2 antibody IHC of human Breast, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

LSBio Ratings

PathPlus™ F2RL1 / PAR2 Antibody (C-Terminus) for IHC LS-A255 has an LSBio Rating of
Laboratory Validation Score (5)

Publications (0)

Customer Reviews (0)


Requested From: United States
Date Requested: 6/5/2020