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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Catalog Number Size Price
LS-A2897-50 50 µg (1 mg/ml) $425 
EPHB2 / EPH Receptor B2 Antibody - Human Skin Carcinoma: Formalin-Fixed, Paraffin-Embedded (FFPE)
EPHB2 / EPH Receptor B2 Antibody - Human Prostate Carcinoma: Formalin-Fixed, Paraffin-Embedded (FFPE)
EPHB2 / EPH Receptor B2 Antibody - Human Colon Carcinoma: Formalin-Fixed, Paraffin-Embedded (FFPE)
EPHB2 / EPH Receptor B2 Antibody - Human Skin Carcinoma: Formalin-Fixed, Paraffin-Embedded (FFPE)
EPHB2 / EPH Receptor B2 Antibody - Human Prostate Carcinoma: Formalin-Fixed, Paraffin-Embedded (FFPE)
EPHB2 / EPH Receptor B2 Antibody - Human Colon Carcinoma: Formalin-Fixed, Paraffin-Embedded (FFPE)
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PathPlus™ Polyclonal EPHB2 / EPH Receptor B2 Antibody (Internal, IHC) LS‑A2897

PathPlus™ Polyclonal EPHB2 / EPH Receptor B2 Antibody (Internal, IHC) LS‑A2897

Antibody:
Rabbit Polyclonal to Human EPHB2 / EPH Receptor B2
Application:
IHC, IHC-P
Reactivity:
Human, Monkey, Mouse, Rat, Rabbit, Zebrafish
Format:
Unconjugated, Unmodified
Other formats:
Price
Catalog Number
$425 
LS-A2897-50
50 µg
1 mg/ml

Toll Free North America
866-819-4732

Overview

Antibody:
Rabbit Polyclonal to Human EPHB2 / EPH Receptor B2
Application:
IHC, IHC-P
Reactivity:
Human, Monkey, Mouse, Rat, Rabbit, Zebrafish
Format:
Unconjugated, Unmodified
Other formats:

Specifications

Description
EPHB2 is a receptor tyrosine kinase that binds transmembrane ephrin-B family ligands residing on adjacent cells. This leads to contact-dependent bidirectional signaling into neighboring cells. EPHB2 has important functions in axon guidance during development, and participates in the guidance of commissural axons that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. It is also involved in the guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. In addition to axon guidance, EPHB2 regulates dendritic spine development and maturation and stimulates the formation of excitatory synapses. EPHB2 also controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production. In breast cancer, EPHB2 expression is positively correlated with HER2 expression. Furthermore, localization of EPHB2 is associated with survival; cytoplasmic positivity in cancer cells may be predictive of poor prognosis while primarily membranous staining may indicate better overall recurrence-free survival. In immunohistochemistry, EPHB2 has membranous and cytoplasmic positivity in many tissues throughout the body. It is found in neurons throughout the brain, with high positivity in the cerebral cortex, hippocampus, basal ganglia and cerebellum. References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804; Oncotarget. 2016 Apr 19;7(16):21362-80, PMID: 26870995;
Target
Human EPHB2 / EPH Receptor B2
Synonyms
EPHB2 | CAPB | Cek5 | EK5 | ETECK | EPH tyrosine kinase 3 | DRT | ELK-related tyrosine kinase | Hek5 | EPH-like kinase 5 | EPHT3 | Nuk | PCBC | Tyrosine-protein kinase TYRO5 | Protein-tyrosine kinase HEK5 | Tyro5 | EPH receptor B2 | Ephrin type-B receptor 2 | EPTH3
Host
Rabbit
Reactivity
Human, Monkey, Mouse, Rat, Rabbit, Zebrafish (tested or 100% immunogen sequence identity)
Predicted
Bovine, Hamster, Pig, Chicken (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (1:100)
  • Applications tested for the base form of this product only
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
Synthetic 15 amino acid peptide from internal region of human EPHB2. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Marmoset, Mouse, Rat, Panda, Rabbit, Opossum, Zebrafish (100%); Hamster, Elephant, Bovine, Pig, Turkey, Chicken, Pufferfish (93%); Xenopus, Seabass (87%); Stickleback (80%).
Blocking Peptide
LS-E28656 - Liquid - 50 µg - $145.00
Immunizing peptide used to generate LS-A2897. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
Epitope
Internal
Specificity
Human EPHB2. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About EPHB2 / EPH Receptor B2
P29323 NM_017449 AAB94602.1

Validation

EPHB2 / EPH Receptor B2 Antibody - Human Skin Carcinoma: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Skin Carcinoma: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Skin Carcinoma: Formalin-Fixed, Paraffin-Embedded (FFPE)

EPHB2 / EPH Receptor B2 Antibody - Human Prostate Carcinoma: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Prostate Carcinoma: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Prostate Carcinoma: Formalin-Fixed, Paraffin-Embedded (FFPE)

EPHB2 / EPH Receptor B2 Antibody - Human Colon Carcinoma: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Colon Carcinoma: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Colon Carcinoma: Formalin-Fixed, Paraffin-Embedded (FFPE)

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Requested From: United States
Date Requested: 2/19/2020