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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Catalog Number Size Price
LS-A2841-50 50 µg (1 mg/ml) $425 
EPHA4 / EPH Receptor A4 Antibody - Anti-EPHA4 antibody IHC of human kidney, glomerulus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

PathPlus™ EPHA4 / EPH Receptor A4 Antibody Internal Polyclonal IHC LS‑A2841

PathPlus™ EPHA4 / EPH Receptor A4 Antibody Internal Polyclonal IHC LS‑A2841

Antibody:
Rabbit Polyclonal to Human EPHA4 / EPH Receptor A4
Application:
IHC, IHC-P
Reactivity:
Human, Monkey, Bat, Bovine, Dog, Horse, Pig
Format:
Unconjugated, Unmodified
Other formats:
Price
Catalog Number
$425 
LS-A2841-50
50 µg
1 mg/ml
Toll Free North America
866-819-4732

Overview

Antibody:
Rabbit Polyclonal to Human EPHA4 / EPH Receptor A4
Application:
IHC, IHC-P
Reactivity:
Human, Monkey, Bat, Bovine, Dog, Horse, Pig
Format:
Unconjugated, Unmodified
Other formats:

Specifications

Description
EPHA4 is a receptor tyrosine kinase that binds membrane-bound ephrin to induce bidirectional signaling into neighboring cells. EPHA4 regulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac, Rap and Rho GTPases activity. It plays an important role in the development of the nervous system, controlling different steps of axonal guidance including the establishment of the corticospinal projections. It may also control the segregation of motor and sensory axons during neuromuscular circuit development. It is also involved in synaptic plasticity, injury repair, and angiogenesis in the central nervous system. In amyotrophic lateral sclerosis and other neurodegenerative diseases, EPHA4 plays an important role in the degeneration of neurons and in disease progression, and is a putative therapy target. In immunohistochemistry, EPHA4 has highest cytoplasmic positivity in the brain, and it is also found in the thyroid, respiratory epithelial cells in the lung, reproductive tissues, skin, immune tissues, and at lower levels elsewhere. J Neurosci. 2011 Dec 14;31(50):18364-80, PMID: 22171039; J Neurosci. 2007 Dec 19;27(51):14205-15, PMID: 18094260; J Neurochem. 2010 Apr;113(1):153-65; Cell Chem Biol. 2017 Mar 16;24(3):293-305, PMID: 28196613
Target
Human EPHA4 / EPH Receptor A4
Host
Rabbit
Reactivity
Human, Monkey, Bat, Bovine, Dog, Horse, Pig (tested or 100% immunogen sequence identity)
Predicted
Mouse, Rat, Hamster, Rabbit, Xenopus (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (3 µg/ml)
  • Applications tested for the base form of this product only
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
Synthetic 18 amino acid peptide from internal region of human EPHA4. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Panda, Bovine, Dog, Bat, Horse, Pig (100%); Mouse, Rat, Hamster, Elephant, Rabbit, Opossum, Platypus, Xenopus (94%); Turkey, Chicken (89%); Lizard (83%).
Blocking Peptide
LS-E28637 - Liquid - 50 µg - $145.00
Immunizing peptide used to generate LS-A2841. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
Epitope
Internal
Specificity
Human EPHA4. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About EPHA4 / EPH Receptor A4
P54764 NM_004438 NP_004429.1

Validation

EPHA4 / EPH Receptor A4 Antibody - Anti-EPHA4 antibody IHC of human kidney, glomerulus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-EPHA4 antibody IHC of human kidney, glomerulus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-EPHA4 antibody IHC of human kidney, glomerulus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

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Requested From: United States
Date Requested: 11/17/2019