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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Catalog Number Size Price
LS-B7710-50 50 µl $425 
DDC / DOPA Decarboxylase Antibody - Anti-AADC / DOPA Decarboxylase antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
DDC / DOPA Decarboxylase Antibody - Western blot of 5 µg of bovine adrenal medulla lysate showing specific immunolabeling of the ~55k DOPA decarboxylase protein.
DDC / DOPA Decarboxylase Antibody - Anti-AADC / DOPA Decarboxylase antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
DDC / DOPA Decarboxylase Antibody - Western blot of 5 µg of bovine adrenal medulla lysate showing specific immunolabeling of the ~55k DOPA decarboxylase protein.
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PathPlus™ Polyclonal Rabbit anti‑Human DDC / DOPA Decarboxylase Antibody (N‑Terminus, IHC, WB) LS‑B7710

PathPlus™ Polyclonal Rabbit anti‑Human DDC / DOPA Decarboxylase Antibody (N‑Terminus, IHC, WB) LS‑B7710

Note: This antibody replaces LS-C180
Antibody:
Rabbit Polyclonal to Human DDC / DOPA Decarboxylase
Application:
IHC, IHC-P, WB
Reactivity:
Human, Rat, Bovine, Dog, Guinea pig, Sheep
Format:
Unconjugated, Unmodified
Price
Catalog Number
$425 
LS-B7710-50
50 µl
Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
Rabbit Polyclonal to Human DDC / DOPA Decarboxylase
Application:
IHC, IHC-P, WB
Reactivity:
Human, Rat, Bovine, Dog, Guinea pig, Sheep
Format:
Unconjugated, Unmodified

Specifications

Description
DDC (Aromatic L-amino acid decarboxylase, DOPA decarboxylase, AADC, AAAD) is a lyase that catalyzes the decarboxylation reactions for a number of neurotransmitters and neuromodulators including dopamine, serotonin, histamine and phenylalanine. DDC is required for normal neural function. It can also be a rate-limiting step in dopamine and serotonin synthesis, specifically in Parkinson’s disease patients treated with L-DOPA and in dysthymia or depression patients treated with 5-HTP. Deficiency of DDC is associated with developmental delay, autonomic dysfunction and oculogyric crises, and inherited polymorphisms in DDC may contribute to various neuropsychiatric phenotypes and conditions. In immunohistochemistry of normal tissue, DDC has highest cytoplasmic positivity in renal tissues and is also found in the cerebral cortex, appendix, lung, liver, gastrointestinal tract, prostate, breast and in endocrine and reproductive tissues. References: BioMed Research International. 2013. Volume 2013 (161456), DOI:10.1155/2013/161456; Neuropsychopharmacology. 2016 Aug; 41(9): 2303–2308; 26924680;
Target
Human DDC / DOPA Decarboxylase
Synonyms
DDC | AADC | DOPA decarboxylase
Host
Rabbit
Reactivity
Human, Rat, Bovine, Dog, Guinea pig, Sheep (tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (1:100)
  • Western blot (1:1000)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
Peptide from N-Terminus of human DOPA decarboxylase (DDC), conjugated to keyhole limpet hemocyanin (KLH).
Epitope
N-Terminus
Specificity
Specific for the ~55k DDC protein
Presentation
10 mM HEPES, pH 7.5, 150 mM NaCl, 50% Glycerol, 100 ug/ml BSA
Storage
Short term: store at 4°C. Long term: store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About DDC / DOPA Decarboxylase
P20711 NM_000790 NP_000781.1

Validation

DDC / DOPA Decarboxylase Antibody - Anti-AADC / DOPA Decarboxylase antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
Anti-AADC / DOPA Decarboxylase antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
Anti-AADC / DOPA Decarboxylase antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.

LSBio Ratings

PathPlus™ DDC / DOPA Decarboxylase Antibody (N-Terminus) for IHC, WB/Western LS-B7710 has an LSBio Rating of
Laboratory Validation Score (5)

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Requested From: United States
Date Requested: 6/6/2020