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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Catalog Number Size Price
LS-B6211-50 50 µg $495 
CORO1A / Coronin 1a Antibody - Anti-CORO1A antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3 ug/ml.
CORO1A / Coronin 1a Antibody - Western blot of CORO1A expression in K-562.
CORO1A / Coronin 1a Antibody - Detection limit for recombinant GST tagged CORO1A is approximately 0.1 ng/ml as a capture antibody.
CORO1A / Coronin 1a Antibody - Anti-CORO1A antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3 ug/ml.
CORO1A / Coronin 1a Antibody - Western blot of CORO1A expression in K-562.
CORO1A / Coronin 1a Antibody - Detection limit for recombinant GST tagged CORO1A is approximately 0.1 ng/ml as a capture antibody.
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PathPlus™ Monoclonal Mouse anti‑Human CORO1A / Coronin 1a Antibody (clone 4G10, IHC, WB) LS‑B6211

PathPlus™ Monoclonal Mouse anti‑Human CORO1A / Coronin 1a Antibody (clone 4G10, IHC, WB) LS‑B6211

Note: This antibody replaces LS-C133678
Antibody:
Mouse Monoclonal to Human CORO1A / Coronin 1a
Application:
IHC, IHC-P, WB, ELISA
Reactivity:
Human
Format:
Unconjugated, Unmodified
Price
Catalog Number
$495 
LS-B6211-50
50 µg
Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
Mouse Monoclonal to Human CORO1A / Coronin 1a
Application:
IHC, IHC-P, WB, ELISA
Reactivity:
Human
Format:
Unconjugated, Unmodified

Specifications

Description
CORO1A is a protein found in macrophages and is involved in phagocytosis, mitochondrial apoptosis and T-cell mediated immunity. It is an important component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria-infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes. CORO1A also has important functions in circuit formation in the developing nervous system; it helps to ensure that axons form stable connections and prevents overgrowth by suppressing the sympathetic neuron growth rate. Separately, expression of CORO1A has been found to be negatively associated with age in humans. In immunohistochemistry, CORO1A has highest cytoplasmic positivity in lymphoid tissue, followed by expression in the cerebral cortex, hippocampus and caudate in the brain, as well as limited positivity in the skin and a few other tissues. References: Aging Cell. 8 (3): 239–50, PMID: 19245677; Biochemistry. 48. pp. 116–23, PMID: 18925376; J Neurosci. 2015 Mar 4; 35(9): 3893–3902, PMID: 25740518
Target
Human CORO1A / Coronin 1a
Synonyms
CORO1A | Clipin-A | Coronin-like protein A | Coronin-like protein p57 | CLIPINA | Coronin-1 | Coronin-1A | HCORO1 | p57 | TACO | CLABP | CORO1
Host
Mouse
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG2a,k Monoclonal
Clone
4G10
Conjugations
Unconjugated
Purification
Purified from ascites by Protein A
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (3 - 5 µg/ml)
  • Western blot (1:500 - 1:1000)
  • ELISA
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
CORO1A (NP_009005, 360 aa ~ 462 aa) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human CORO1A
Usage
Immunohistochemistry: Formalin-fixed paraffin-embedded sections. Sandwich ELISA: Recombinant protein. Western Blot using cell line lysates and the recombinant protein used as the immunogen.
Presentation
PBS, pH 7.4
Storage
Store at -20°C or lower. Aliquot to avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About CORO1A / Coronin 1a
P31146 NM_007074 NP_009005.1

Validation

CORO1A / Coronin 1a Antibody - Anti-CORO1A antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3 ug/ml.
Anti-CORO1A antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3 ug/ml.
Anti-CORO1A antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3 ug/ml.

LSBio Ratings

PathPlus™ CORO1A / Coronin 1a Antibody (clone 4G10) for IHC, WB/Western, ELISA LS-B6211 has an LSBio Rating of
Laboratory Validation Score (5)

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Requested From: United States
Date Requested: 5/24/2020