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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Catalog Number Size Price
LS-A1338-50 50 µg (1 mg/ml) $425 
CHRM5 / M5 Antibody - Brain, Pituitary
CHRM5 / M5 Antibody - Anti-CHRM5 antibody IHC of human brain, vessel. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
CHRM5 / M5 Antibody - Anti-CHRM5 / M5 antibody IHC of human Lung, Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
CHRM5 / M5 Antibody - Brain, Pituitary
CHRM5 / M5 Antibody - Anti-CHRM5 antibody IHC of human brain, vessel. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
CHRM5 / M5 Antibody - Anti-CHRM5 / M5 antibody IHC of human Lung, Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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PathPlus™ Polyclonal Rabbit anti‑Human CHRM5 / M5 Antibody (Cytoplasmic Domain, IHC) LS‑A1338

PathPlus™ Polyclonal Rabbit anti‑Human CHRM5 / M5 Antibody (Cytoplasmic Domain, IHC) LS‑A1338

Antibody:
Rabbit Polyclonal to Human CHRM5 / M5
Application:
IHC, IHC-P
Reactivity:
Human, Monkey
Format:
Unconjugated, Unmodified
Other formats:
Price
Catalog Number
$425 
LS-A1338-50
50 µg
1 mg/ml

Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
Rabbit Polyclonal to Human CHRM5 / M5
Application:
IHC, IHC-P
Reactivity:
Human, Monkey
Format:
Unconjugated, Unmodified
Other formats:

Specifications

Description
Cholinergic receptor, muscarinic 5 (CHRM5) is a receptor for acetylcholine and is involved in adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. CHRM5 influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, stimulation of this receptor is known to increase cyclic AMP levels. References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804
Target
Human CHRM5 / M5
Synonyms
CHRM5 | M5 muscarinic receptor | Muscarinic m5 receptor | Muscarinic receptor M5 | HM5
Host
Rabbit
Reactivity
Human, Monkey (tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (6 µg/ml)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
Synthetic 16 amino acid peptide from 3rd cytoplasmic domain of human CHRM5. Percent identity with other species by BLAST analysis: Human, Gorilla, Monkey (100%); Gibbon (94%); Chimpanzee, Marmoset (88%); Dog, Bovine, Panda, Horse (81%).
Epitope
Cytoplasmic Domain
Specificity
Human CHRM5. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About CHRM5 / M5
P08912 NM_012125 NP_036257.1

Validation

CHRM5 / M5 Antibody - Brain, Pituitary
Brain, Pituitary
Brain, Pituitary

CHRM5 / M5 Antibody - Anti-CHRM5 antibody IHC of human brain, vessel. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-CHRM5 antibody IHC of human brain, vessel. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-CHRM5 antibody IHC of human brain, vessel. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

CHRM5 / M5 Antibody - Anti-CHRM5 / M5 antibody IHC of human Lung, Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-CHRM5 / M5 antibody IHC of human Lung, Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-CHRM5 / M5 antibody IHC of human Lung, Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

LSBio Ratings

PathPlus™ CHRM5 / M5 Antibody (Cytoplasmic Domain) for IHC LS-A1338 has an LSBio Rating of
Laboratory Validation Score (5)

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Requested From: United States
Date Requested: 7/2/2020