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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Catalog Number Size Price
LS-A4254-50 50 µg (1 mg/ml) $425 
CCR7 Antibody - Hodgkin's disease Reed Sternberg cells
CCR7 Antibody - Lymph node, eosinophilic granuloma Langerhans histiocytes
CCR7 Antibody - Anti-CCR7 antibody IHC staining of human lymph node. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
CCR7 Antibody - Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
CCR7 Antibody - Hodgkin's disease Reed Sternberg cells
CCR7 Antibody - Lymph node, eosinophilic granuloma Langerhans histiocytes
CCR7 Antibody - Anti-CCR7 antibody IHC staining of human lymph node. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
CCR7 Antibody - Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
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PathPlus™ Polyclonal CCR7 Antibody (Extracellular Domain, IHC) LS‑A4254

PathPlus™ Polyclonal CCR7 Antibody (Extracellular Domain, IHC) LS‑A4254

Antibody:
Rabbit Polyclonal to Human CCR7
Application:
IHC, IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:
Price
Catalog Number
$425 
LS-A4254-50
50 µg
1 mg/ml

Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
Rabbit Polyclonal to Human CCR7
Application:
IHC, IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:

Specifications

Description
Chemokine (C-C motif) receptor 7 (CCR7) is involved in lymphocyte recirculation through secondary lymphoid organs and moving lymphocytes and dendritic cells into distinct tissue compartments. CCR7 is called the Epstein-Barr-induced receptor because it mediates Epstein-Barr viral effects on B lymphocytes. CCR7 expression is up-regulated in mature dendritic cells, B cells infected with EBV, and in CD4+ cells infected with human herpes virus 6 and 7. Immature dendritic cells have been shown to express chemokine receptor 5 (CCR5) and migrate in response to macrophage inflammatory protein-1alpha (MIP-1alpha), whereas mature dendritic cells switch to CCR7 expression and respond exclusively to MIP-3beta and 6Ckine. Maturing dendritic cells upregulate CCR7, which drives their migration to the T-cell areas of the draining lymph nodes where antigen is presented to naive T cells. References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804
Target
Human CCR7
Synonyms
CCR7 | BLR2 | Chemokine (C-C) receptor 7 | CD197 | C-C CKR-7 | CMKBR7 | CC chemokine receptor 7 | CCR-7 | CD197 antigen | CDw197 | EBI1 | EVI1 | MIP-3 beta receptor | C-c chemokine receptor 7 | C-C chemokine receptor type 7 | CC-CKR-7 | Chemokine c-c motif receptor 7
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (10 - 20 µg/ml)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
Synthetic 16 amino acid peptide from 1st extracellular domain of human CCR7. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey (100%); Bovine, Pig (94%); Marmoset, Elephant, Bat, Horse, Rabbit (88%); Panda, Dog (81%).
Epitope
Extracellular Domain
Specificity
Human CCR7. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except GPR141 (44%).
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About CCR7
P32248 NM_001838 NP_001829.1

Validation

CCR7 Antibody - Hodgkin's disease Reed Sternberg cells
Hodgkin's disease Reed Sternberg cells
Hodgkin's disease Reed Sternberg cells

CCR7 Antibody - Lymph node, eosinophilic granuloma Langerhans histiocytes
Lymph node, eosinophilic granuloma Langerhans histiocytes
Lymph node, eosinophilic granuloma Langerhans histiocytes

CCR7 Antibody - Anti-CCR7 antibody IHC staining of human lymph node. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-CCR7 antibody IHC staining of human lymph node. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-CCR7 antibody IHC staining of human lymph node. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

CCR7 Antibody - Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)

LSBio Ratings

PathPlus™ CCR7 Antibody (Extracellular Domain) for IHC LS-A4254 has an LSBio Rating of
Laboratory Validation Score (5)

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Requested From: United States
Date Requested: 4/1/2020