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Catalog Number Size Price
LS-A273-50 50 µg (1 mg/ml) $425 
AVPR2 / V2R Antibody - Lung, Adenocarcinoma
AVPR2 / V2R Antibody - Pancreas, carcinoma
AVPR2 / V2R Antibody - Ovary, carcinoma
AVPR2 / V2R Antibody - Colon, carcinoma
AVPR2 / V2R Antibody - Anti-AVPR2 antibody IHC of human kidney, renal tubules. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
AVPR2 / V2R Antibody - Colon, Carcinoma
AVPR2 / V2R Antibody - Anti-AVPR2 / V2R antibody IHC of human Lung, Adenocarcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
AVPR2 / V2R Antibody - Lung, Adenocarcinoma
AVPR2 / V2R Antibody - Pancreas, carcinoma
AVPR2 / V2R Antibody - Ovary, carcinoma
AVPR2 / V2R Antibody - Colon, carcinoma
AVPR2 / V2R Antibody - Anti-AVPR2 antibody IHC of human kidney, renal tubules. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
AVPR2 / V2R Antibody - Colon, Carcinoma
AVPR2 / V2R Antibody - Anti-AVPR2 / V2R antibody IHC of human Lung, Adenocarcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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PathPlus™ Polyclonal AVPR2 / V2R Antibody (C‑Terminus, IHC) LS‑A273

PathPlus™ Polyclonal AVPR2 / V2R Antibody (C‑Terminus, IHC) LS‑A273

Antibody:
Rabbit Polyclonal to Human AVPR2 / V2R
Application:
IHC, IHC-P
Reactivity:
Human, Monkey
Format:
Unconjugated, Unmodified
Other formats:
Price
Catalog Number
$425 
LS-A273-50
50 µg
1 mg/ml

Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
Rabbit Polyclonal to Human AVPR2 / V2R
Application:
IHC, IHC-P
Reactivity:
Human, Monkey
Format:
Unconjugated, Unmodified
Other formats:

Specifications

Description
AVPR2 / V2R is the vasopressin receptor, type 2, also known as the V2 receptor, which belongs to the seven-transmembrane-domain G protein-coupled receptor (GPCR) superfamily, and couples to Gs thus stimulating adenylate cyclase. The subfamily that includes the V2 receptor, the V1a and V1b vasopressin receptors, the oxytocin receptor, and isotocin and mesotocin receptors in non-mammals, is well conserved, though several members signal via other G proteins. All bind similar cyclic nonapeptide hormones. The V2 receptor is expressed in the kidney tubule, predominantly in the distal convoluted tubule and collecting ducts, where its primary property is to respond to the pituitary hormone arginine vasopressin (AVP) by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. When the function of this gene is lost, the disease Nephrogenic Diabetes Insipidus (NDI) results. The V2 receptor is also expressed outside the kidney although its tissue localization is uncertain. When these 'extrarenal receptors' are stimulated by infusion of a V2 selective agonist (dDAVP), a variety of clotting factors are released into the bloodstream. The physiologic importance of this property is not known - its absence does not appear to be detrimental in NDI patients. The gene expression has also been described in fetal lung tissue and lung cancer associated with alternative splicing. References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804
Target
Human AVPR2 / V2R
Synonyms
AVPR2 | ADHR | AVPR V2 | Avp2r | Antidiuretic hormone receptor | DI1 | DIR3 | NDI | Vasopressin type 2 receptor | Vasopressin type II receptor | Vasopressin V2 receptor | V2 vasopressin receptor | Vasopressin receptor type 2 | DIR | Type 2 vasopressin receptor | V2-renal V2R | V2R
Host
Rabbit
Reactivity
Human, Monkey (tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (3 - 6 µg/ml)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
Synthetic 15 amino acid peptide from C-Terminus of human AVPR2. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Baboon, Monkey (100%); Marmoset, Panda (87%); Dog (80%).
Blocking Peptide
LS-E28612 - Liquid - 50 µg - $145.00
Immunizing peptide used to generate LS-A273. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
Epitope
C-Terminus
Specificity
Human AVPR2. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About AVPR2 / V2R
P30518 NM_000054 NP_000045.1

Validation

AVPR2 / V2R Antibody - Lung, Adenocarcinoma
Lung, Adenocarcinoma
Lung, Adenocarcinoma

AVPR2 / V2R Antibody - Pancreas, carcinoma
Pancreas, carcinoma
Pancreas, carcinoma

AVPR2 / V2R Antibody - Ovary, carcinoma
Ovary, carcinoma
Ovary, carcinoma

AVPR2 / V2R Antibody - Colon, carcinoma
Colon, carcinoma
Colon, carcinoma

AVPR2 / V2R Antibody - Anti-AVPR2 antibody IHC of human kidney, renal tubules. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-AVPR2 antibody IHC of human kidney, renal tubules. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-AVPR2 antibody IHC of human kidney, renal tubules. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

AVPR2 / V2R Antibody - Colon, Carcinoma
Colon, Carcinoma
Colon, Carcinoma

AVPR2 / V2R Antibody - Anti-AVPR2 / V2R antibody IHC of human Lung, Adenocarcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-AVPR2 / V2R antibody IHC of human Lung, Adenocarcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-AVPR2 / V2R antibody IHC of human Lung, Adenocarcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

LSBio Ratings

PathPlus™ AVPR2 / V2R Antibody (C-Terminus) for IHC LS-A273 has an LSBio Rating of
Laboratory Validation Score (5)

Publications (0)

Customer Reviews (0)


Requested From: United States
Date Requested: 3/29/2020