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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Catalog Number Size Price
LS-B1608-1 1 ea (1 mg/ml) $425 
PTGS2 / COX2 / COX-2 Antibody - Anti-COX-2 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
PTGS2 / COX2 / COX-2 Antibody - Western blot of COX-2 antibody.
PTGS2 / COX2 / COX-2 Antibody - Anti-COX-2 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
PTGS2 / COX2 / COX-2 Antibody - Western blot of COX-2 antibody.
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PathPlus™ PTGS2 / COX2 / COX‑2 Antibody aa550‑600 Polyclonal ICC,IHC,WB LS‑B1608

PathPlus™ PTGS2 / COX2 / COX‑2 Antibody aa550‑600 Polyclonal ICC,IHC,WB LS‑B1608

Note: This antibody replaces LS-C11709
Antibody:
Goat Polyclonal to Human PTGS2 / COX2 / COX-2
Application:
IHC, IHC-P, ICC, WB
Reactivity:
Human, Mouse, Rat, Sheep
Format:
Unconjugated, Unmodified
Price
Catalog Number
$425 
LS-B1608-1
1 ea
1 mg/ml
Toll Free North America
866-819-4732

Overview

Antibody:
Goat Polyclonal to Human PTGS2 / COX2 / COX-2
Application:
IHC, IHC-P, ICC, WB
Reactivity:
Human, Mouse, Rat, Sheep
Format:
Unconjugated, Unmodified

Specifications

Description
Cyclooxygenase 2 (COX-2 / PTGS2/ prostaglandin-endoperoxide synthase 2) is an enzyme involved in the conversion of arachidonic acid to prostaglandin H2, a precursor of prostacyclin that is released during inflammation. Unlike COX1, which is constitutively expressed, COX2 is induced upon inflammation. COX2 is a frequent target for inhibitors (coxibs) to treat inflammatory conditions. Aspirin and nonsteroidal anti-inflammatory agents also inhibit prostaglandin and prostacyclin production by COX2. Overexpression of COX2 also occurs in many cancers, and COX2 inhibitors may assist in preventing the development of colorectal cancers. Staining for COX2 is expected to be cytoplasmic and potentially membranous. In normal tissues, it is expressed in a variety of cells including endothelial cells, smooth muscle cells, cardiac myocytes, the brain and spinal cord, kidney, the GI tract, lung and bladder. Biochem Soc Transact 2008 36(3):543; Nat Reviews Drug Discovery 2003 2:179; J Cell Phys 2019 234(5):5683; Gastroenterology 1994 107(4):1183, Curr Med Chem 2000 7(11):1113; PNAS 2016 113(2):434
Target
Human PTGS2 / COX2 / COX-2
Host
Goat
Reactivity
Human, Mouse, Rat, Sheep (tested or 100% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (5 µg/ml)
  • ICC (1 - 2 µg/ml)
  • Western blot (2 µg/ml)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
Synthetic peptide from human PTGS2 / COX-2.
Epitope
aa550-600
Usage
Immunohistochemistry: LS-B1608 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B1608 was determined to be 5 ug/ml.
Presentation
TBS, pH 7.4, 0.02% Sodium Azide, 50% Glycerol, 0.1% BSA
Storage
Short term: -20°C; Long term: -20°C.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About PTGS2 / COX2 / COX-2
P35354 NM_000963 NP_000954.1

Validation

PTGS2 / COX2 / COX-2 Antibody - Anti-COX-2 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Anti-COX-2 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Anti-COX-2 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

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Requested From: United States
Date Requested: 12/10/2019