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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Cell Cycle Pathways
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Catalog Number Size Price
LS-B6101-100 100 µg (0.35 mg/ml) $485 
FOXA1 Antibody - Anti-FOXA1 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
FOXA1 Antibody - Immunofluorescence of monoclonal antibody to FOXA1 on HeLa cell. [antibody concentration 10 ug/ml]
FOXA1 Antibody - Western blot of FOXA1 expression in HepG2 cell lysate.
FOXA1 Antibody - Western blot of FOXA1 expression in MCF-7 cell lysate.
FOXA1 Antibody - Anti-FOXA1 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
FOXA1 Antibody - Immunofluorescence of monoclonal antibody to FOXA1 on HeLa cell. [antibody concentration 10 ug/ml]
FOXA1 Antibody - Western blot of FOXA1 expression in HepG2 cell lysate.
FOXA1 Antibody - Western blot of FOXA1 expression in MCF-7 cell lysate.
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PathPlus™ FOXA1 Antibody Monoclonal ELISA,IF,IHC,WB LS‑B6101

PathPlus™ FOXA1 Antibody Monoclonal ELISA,IF,IHC,WB LS‑B6101

Note: This antibody replaces LS-C133250
Antibody:
Mouse Monoclonal to Human FOXA1
Application:
IHC, IHC-P, IF, WB, ELISA
Reactivity:
Human
Format:
Unconjugated, Unmodified
Price
Catalog Number
$485 
LS-B6101-100
100 µg
0.35 mg/ml
Toll Free North America
866-819-4732

Overview

Antibody:
Mouse Monoclonal to Human FOXA1
Application:
IHC, IHC-P, IF, WB, ELISA
Reactivity:
Human
Format:
Unconjugated, Unmodified

Specifications

Description
FOXA1 (forkhead box A1, hepatocyte neuclear factor 3a, HNF3A) is a forkhead box domain transcription factor and nuclear steroid receptor involved in mediating sex hormone-dependent signaling in the differentiation and development of tissues such as the pancreas, liver, breast and prostate. Expression of FOXA1 has been associated with a good prognosis in hormone receptor positive breast cancer. It is a useful marker for luminal A type breast cancers, as it is often expressed in luminal subtypes independent of ER expression and it does not see expression in basal subtypes. In ER-negative tumors, a lack of FOXA1 expression is associated with worse prognosis, as loss of FOXA1 is associated with the consequential expression of metastases-prone, basal-specific proteins that it normally acts to directly repress. FOXA1 is expected to show nuclear expression in tissues such as prostate, breast, urothelium, the GI tract and respiratory epithelium. EMBO J. 2011 30(19):3885; Bernardo, 2013; Algergaria, 2001; Gong, 2014; Expert Rev Mol Med 2009 5(11):e8; Breast Cancer Res 2009 11(3):R40; Mol Endocrinol 2010 24(8):1594; Ann Surg Oncol 2012 19(4):1145
Target
Human FOXA1
Host
Mouse
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG1,k Monoclonal
Clone
3C1
Conjugations
Unconjugated
Purification
Purified from ascites by Protein A
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (5 µg/ml)
  • Immunofluorescence (10 µg/ml)
  • Western blot (1:500 - 1:1000)
  • ELISA
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
FOXA1 (NP_004487, 367 aa ~ 473 aa) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human FOXA1
Usage
Immunohistochemistry: Formalin-fixed paraffin-embedded sections. Western Blot: Cell lysate, Cell lysate, Recombinant protein.
Presentation
PBS, pH 7.4
Storage
Store at -20°C or lower. Aliquot to avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About FOXA1
P55317 NM_004496 NP_004487.2

Validation

FOXA1 Antibody - Anti-FOXA1 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Anti-FOXA1 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Anti-FOXA1 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

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Requested From: United States
Date Requested: 11/14/2019