Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Recognizes active rat PAI-1. Pooled normal plasma from mouse and dog was assayed and significant crossreactivity was observed. Pooled normal plasma from human and pig was assayed and minor cross-reactivity was observed. Pooled normal plasma from sheep was assayed and no significant cross-reactivity was observed. Pooled normal plasma from rabbit resulted in significant color development.
LS-F10476 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Rat SERPINE1 / PAI-1 in samples of Plasma and Serum. It is based upon a Functional assay principle and can be used to detect levels of SERPINE1 / PAI-1 as low as 0.079 nanograms per millilter.
96-Well Strip Plate
Colorimetric - 450nm (TMB)
0.1 - 50 ng/ml
Due to their limited shelf life, LSBio ELISA kits are not typically stocked as finished goods. Upon receipt of an order each kit is assembled and tested to ensure that it meets specifications before shipping. Minor changes may occur to the Range, Sensitivity, and Precision. In the event of a significant change the order would be confirmed with the customer before shipping ELISA kit lot numbers reflect the date of final assembly and testing for each specific kit rather than a bulk manufactured lot. All kits are tested to confirm that they fall within their defined Inter- and Intra- assay coefficient of variation.
Plasminogen activator inhibitor-1 (PAI-1) is a serine protease inhibitor that is an important regulator of fibrinolysis and extracellular matrix turnover [1,2,6]. PAI-1 may be important in hepatocyte growth and proliferation in vivo. Increased PAI-1 levels may increase the risk for myocardial infarction, atherosclerosis, and retenosis [3,4]. Increased PAI-1 levels may also play an important role of the development and pathogenesis of diabetic nephropathy. Decreased levels may reduce thrombotic events.
SERPINE1 / PAI-1 is a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia.