Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Farnesoid X Receptor (FXR)
No significant cross-reactivity or interference between Farnesoid X Receptor (FXR) and analogs was observed.
LS-F8975 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the detection of Rat NR1H4 / FXR in samples of Cell Lysates and Tissue Homogenates. It is based upon a Sandwich assay principle and can be used to detect levels of NR1H4 / FXR as low as 0.053 nanograms per millilter.
All LSBio Custom kits have been predesigned and all necessary components, including antibodies and standards have been identified. Upon receiving a custom kit order, the kit will be assembled and quality control tested before being shipped out. Kit assembly and testing typically takes 4 to 6 weeks. In most cases the final kit is based on the Sandwich assay principle, with a few being Competitive EIA based. Specifications such as Range, Sensitivity, and Precision are defined upon completion. In the event that the custom kit cannot be successfully developed with 6 weeks of the order date, the customer will be notified and the order canceled at no cost.
Cell Lysates, Tissue Homogenates
96-Well Strip Plate
Colorimetric - 450nm (TMB)
0.156 - 10 ng/ml
Intra-Assay: CV<10% Inter-Assay: CV<12%
Due to their limited shelf life, LSBio ELISA kits are not typically stocked as finished goods. Upon receipt of an order each kit is assembled and tested to ensure that it meets specifications before shipping. Minor changes may occur to the Range, Sensitivity, and Precision. In the event of a significant change the order would be confirmed with the customer before shipping ELISA kit lot numbers reflect the date of final assembly and testing for each specific kit rather than a bulk manufactured lot. All kits are tested to confirm that they fall within their defined Inter- and Intra- assay coefficient of variation.
NR1H4 Elisa Kit, BAR Elisa Kit, Farnesyl x receptor Elisa Kit, FXR Elisa Kit, HRR1 Elisa Kit, Farnesoid x activated receptor Elisa Kit, Farnesoid X receptor Elisa Kit, Farnesol receptor HRR-1 Elisa Kit, HRR-1 Elisa Kit, RXR-interacting protein 14 Elisa Kit, RIP14 Elisa Kit, Bile acid receptor Elisa Kit, Farnesoid X nuclear receptor Elisa Kit, Farnesoid X-activated receptor Elisa Kit
Farnesoid X receptor (FXR), a NR1 Thyroid Hormone-Like Receptor, has been shown to affect bile-acid metabolism in the liver and intestine. FXR binds to target DNA as a heterodimer (with retinoid X receptors) and is activated by bile acids. Binding of bile acids to the RXR/FXR heterodimer in liver represses CYP7A1 expression and bile-acid production, leading to a failure to solubilize and absorb cholesterol.