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Catalog Number Size Price
LS-H8473-5 5 mg $160 
LS-H8473-10 10 mg $265 
LS-H8473-50 50 mg $1,100 
Biochemical - Licofelone Structure

Licofelone (CAS 156897-06-2) - LS-H8473

Licofelone (CAS 156897-06-2) - LS-H8473

Available for shipment within the USA only
Description:
Cross-talk between lipoxygenase (LO) and cyclooxygenase (COX) pathways has been observed in human osteoarthritic synovial explants which creates an arachidonic acid shunting phenomenon, stimulating interleukin-1Beta (IL-1Beta) synthesis. Licofelone is a dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LO) pathways, that decreases levels of prostaglandin E2, leukotriene B4, and lipoxins and prevents lipopolysaccharide-stimulated IL-1Beta expression. The IC50 values for inhibition of human thrombocyte COX and human 5-LO are 0.16 µM and 0.23 µM, respectively. Unlike other non-steroidal anti-inflammatory drugs, licofelone causes little or no damage to the gastric mucosa in rabbit parietal cells. This is presumably the result of licofelone's affects on acid-secretory mechanisms, mediated by the inhibition of 5-LO activity.
Price
Catalog Number
$160 
LS-H8473-5

Available for shipment within the USA only
Toll Free North America
866-819-4732
For Research Use Only

Overview

Description:
Cross-talk between lipoxygenase (LO) and cyclooxygenase (COX) pathways has been observed in human osteoarthritic synovial explants which creates an arachidonic acid shunting phenomenon, stimulating interleukin-1Beta (IL-1Beta) synthesis. Licofelone is a dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LO) pathways, that decreases levels of prostaglandin E2, leukotriene B4, and lipoxins and prevents lipopolysaccharide-stimulated IL-1Beta expression. The IC50 values for inhibition of human thrombocyte COX and human 5-LO are 0.16 µM and 0.23 µM, respectively. Unlike other non-steroidal anti-inflammatory drugs, licofelone causes little or no damage to the gastric mucosa in rabbit parietal cells. This is presumably the result of licofelone's affects on acid-secretory mechanisms, mediated by the inhibition of 5-LO activity.

Specifications

Conjugations
Unconjugated
CAS Number
156897-06-2
Biological Function
A dual inhibitor of COX-1/COX-2 and 5-LO.
Purity
Greater than 98%
Formal Name
6-(4-chlorophenyl)-2,3-dihydro-2,2-dimethyl-7-phenyl-1H-pyrrolizine-5-acetic acid
Type
Licofelone, ML 3000
Classification
Biochemical, Chemical
Molecular Formula
C23H22ClNO2
Molecular Weight
379.9 g/mol
Formulation
a crystalline solid
Solubility
Solubility in ethanol is approximately 5 mg/ml and approximately 20 mg/ml in DMSO and DMF. Sparingly soluble in aqueous buffers.
λmax
248, 278 nm
SMILES
CC1(C)CC2=C(C3=CC=CC=C3)C(C4=CC=C(Cl)C=C4)=C(CC(O)=O)N2C1
InChI Code
InChI=1S/C23H22ClNO2/c1-23(2)13-19-22(15-6-4-3-5-7-15)21(16-8-10-17(24)11-9-16)18(12-20(26)27)25(19)14-23/h3-11H,12-14H2,1-2H3,(H,26,27)
InChI Key
UAWXGRJVZSAUSZ-UHFFFAOYSA-N
Storage
Store at -20°C for up to 2 years.
Documents
Usage Information
Licofelone is supplied as a crystalline solid. A stock solution may be made by dissolving the licofelone in the solvent of choice. Licofelone is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF), which should be purged with an inert gas. The solubility of licofelone in ethanol is approximately 5 mg/ml and approximately 20 mg/ml in DMSO and DMF. Licofelone is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, licofelone should first be dissolved in DMSO and then diluted with the aqueous buffer of choice. Licofelone has a solubility of approximately 0.5 mg/ml in a 1:8 solution of DMSO:PBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day.
Restrictions
For research use only. Available for shipment within the USA only
Guarantee
This Biochemical carries the LSBio 100% Guarantee

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Images

Biochemical - Licofelone Structure
Licofelone Structure

Biochemical - Licofelone Structure
Licofelone Structure

Biochemical - Licofelone Structure
Licofelone Structure

Biochemical - Licofelone Structure
Licofelone Structure

Requested From: United States
Date Requested: 2/28/2020