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Catalog Number Size Price
LS-H70-5 5 mg $220 
LS-H70-10 10 mg $370 
LS-H70-25 25 mg $780 
Biochemical - HAMI3379 Structure

HAMI3379 (CAS 712313-35-4) - LS-H70

HAMI3379 (CAS 712313-35-4) - LS-H70

Available for shipment within the USA only
Description:
The cysteinyl leukotrienes (CysLTs) LTC4 and LTD4 are potent mediators of asthma and hypersensitivity. They induce bronchoconstriction, increase microvascular permeability, and are vasoconstrictors of coronary arteries. Their biological effects are transduced by a pair of G protein-coupled receptors, CysLT1 and CysLT2. HAMI3379 is a potent cysteinyl leukotriene 2 (CysLT2) receptor antagonist that inhibits radioligand binding of LTD4 to CysLT2 and CysLT1 receptor cell lines with IC50 values of 37.9 and >30,000 nM, respectively. In a CysLT2 receptor reporter cell line, HAMI3379 antagonizes LTD4- and LTC4-induced intracellular calcium mobilization with IC50 values of 3.8 and 4.4 nM, respectively, whereas it only weakly inhibits that for a CysLT1 receptor reporter cell line (IC50 = >10,000 nM). In isolated Langendorff-perfused guinea pig hearts, HAMI3379 reverses the LTC4-stimulated increase in perfusion pressure and decrease in contractility.
Price
Catalog Number
$220 
LS-H70-5

Available for shipment within the USA only
Toll Free North America
866-819-4732
For Research Use Only

Overview

Description:
The cysteinyl leukotrienes (CysLTs) LTC4 and LTD4 are potent mediators of asthma and hypersensitivity. They induce bronchoconstriction, increase microvascular permeability, and are vasoconstrictors of coronary arteries. Their biological effects are transduced by a pair of G protein-coupled receptors, CysLT1 and CysLT2. HAMI3379 is a potent cysteinyl leukotriene 2 (CysLT2) receptor antagonist that inhibits radioligand binding of LTD4 to CysLT2 and CysLT1 receptor cell lines with IC50 values of 37.9 and >30,000 nM, respectively. In a CysLT2 receptor reporter cell line, HAMI3379 antagonizes LTD4- and LTC4-induced intracellular calcium mobilization with IC50 values of 3.8 and 4.4 nM, respectively, whereas it only weakly inhibits that for a CysLT1 receptor reporter cell line (IC50 = >10,000 nM). In isolated Langendorff-perfused guinea pig hearts, HAMI3379 reverses the LTC4-stimulated increase in perfusion pressure and decrease in contractility.

Specifications

Conjugations
Unconjugated
CAS Number
712313-35-4
Biological Function
A potent CysLT 2 receptor antagonist.
Purity
Greater than 90%
Formal Name
3-[[(3-carboxycyclohexyl)amino]carbonyl]-4-[3-[4-[4-(cyclohexyloxy)butoxy]phenyl]propoxy]-benzoic acid
Classification
Biochemical, Chemical, Antagonist
Molecular Formula
C34H45NO8
Molecular Weight
595.7
Formulation
crystalline solid; solubility: 5 mg/ml in ethanol and 20 mg/ml in DMSO and DMF.
λmax
0
SMILES
O=C(NC1CCCC(C(O)=O)C1)C2=CC(C(O)=O)=CC=C2OCCCC(C=C3)=CC=C3OCCCCOC4CCCCC4
InChI Code
1S/C34H39NO8/c36-32(35-27-10-6-9-25(22-27)33(37)38)30-23-26(34(39)40)15-18-31(30)43-21-7-8-24-13-16-29(17-14-24)42-20-5-4-19-41-28-11-2-1-3-12-28/h1-3,11-18,23,25,27H,4-10,19-22H2,(H,35,36)(H,37,38)(H,39,40)
InChI Key
GKPAULTWHHPIHX-UHFFFAOYSA-N
Storage
Store at -20°C.
Stability
24 months
Documents
Usage Information
HAMI3379 is supplied as a crystalline solid. A stock solution may be made by dissolving the HAMI3379 in the solvent of choice. HAMI3379 is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF), which should be purged with an inert gas. The solubility of HAMI3379 in ethanol is approximately 5 mg/ml and approximately 20 mg/ml in DMSO and DMF. HAMI3379 is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, HAMI3379 should first be dissolved in DMF and then diluted with the aqueous buffer of choice. HAMI3379 has a solubility of approximately 0.5 mg/ml in a 1:1 solution of DMF:PBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day.
Restrictions
For research use only. Available for shipment within the USA only
Guarantee
This Biochemical carries the LSBio 100% Guarantee

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Images

Biochemical - HAMI3379 Structure
HAMI3379 Structure

Biochemical - HAMI3379 Structure
HAMI3379 Structure

Biochemical - HAMI3379 Structure
HAMI3379 Structure

Biochemical - HAMI3379 Structure
HAMI3379 Structure

Requested From: United States
Date Requested: 2/28/2020