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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Cell Cycle Pathways
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Catalog Number Size Price
LS-H7985-5 5 mg $70 
LS-H7985-10 10 mg $115 
LS-H7985-25 25 mg $220 
LS-H7985-100 100 mg $465 
Biochemical - GS-9620 Structure

GS-9620 (CAS 1228585-88-3) - LS-H7985

GS-9620 (CAS 1228585-88-3) - LS-H7985

Available for shipment within the USA only
Description:
GS-9620 is an orally available agonist of toll-like receptor 7 (TLR7; EC50 = 291 nM) with 30-fold selectivity over TLR8 (EC50 = 9 µM). It has been shown to stimulate a TLR7 immune response in two different animal models of chronic hepatitis B infection and to inhibit HIV-1 infection in human peripheral blood mononuclear cells.
Price
Catalog Number
$70 
LS-H7985-5

Available for shipment within the USA only
Toll Free North America
866-819-4732
For Research Use Only

Overview

Description:
GS-9620 is an orally available agonist of toll-like receptor 7 (TLR7; EC50 = 291 nM) with 30-fold selectivity over TLR8 (EC50 = 9 µM). It has been shown to stimulate a TLR7 immune response in two different animal models of chronic hepatitis B infection and to inhibit HIV-1 infection in human peripheral blood mononuclear cells.

Specifications

Conjugations
Unconjugated
CAS Number
1228585-88-3
Biological Function
A TLR7 agonist.
Purity
Greater than 98%
Formal Name
4-amino-2-butoxy-7,8-dihydro-8-[[3-(1-pyrrolidinylmethyl)phenyl]methyl]-6(5H)-pteridinone
Type
GS-9620, Vesatolimod
Classification
Biochemical, Chemical
Molecular Formula
C22H30N6O2
Molecular Weight
410.5 g/mol
Formulation
a crystalline solid
Solubility
Approximately 0.25 mg/ml in a 1:3 solution of DMSO:PBS (pH 7.2)
λmax
214, 282 nm
SMILES
O=C(NC1=C2N=C(OCCCC)N=C1N)CN2CC3=CC(CN4CCCC4)=CC=C3
InChI Code
InChI=1S/C22H30N6O2/c1-2-3-11-30-22-25-20(23)19-21(26-22)28(15-18(29)24-19)14-17-8-6-7-16(12-17)13-27-9-4-5-10-27/h6-8,12H,2-5,9-11,13-15H2,1H3,(H,24,29)(H2,23,25,26)
InChI Key
VFOKSTCIRGDTBR-UHFFFAOYSA-N
Storage
Store at -20°C for up to 2 years.
Documents
Usage Information
GS-9620 is supplied as a crystalline solid. A stock solution may be made by dissolving the GS-9620 in the solvent of choice. GS-9620 is soluble in organic solvents such as DMSO and dimethyl formamide, which should be purged with an inert gas. The solubility of GS-9620 in these solvents is approximately 15 and 1 mg/ml, respectively. GS-9620 is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, GS-9620 should first be dissolved in DMSO and then diluted with the aqueous buffer of choice. GS-9620 has a solubility of approximately 0.25 mg/ml in a 1:3 solution of DMSO:PBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day.
Restrictions
For research use only. Available for shipment within the USA only
Guarantee
This Biochemical carries the LSBio 100% Guarantee

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Images

Biochemical - GS-9620 Structure
GS-9620 Structure

Biochemical - GS-9620 Structure
GS-9620 Structure

Biochemical - GS-9620 Structure
GS-9620 Structure

Biochemical - GS-9620 Structure
GS-9620 Structure

Requested From: United States
Date Requested: 2/28/2020