upregulates nnos (neuronal nitric oxide synthase/nos i) and decreases acute inflammation through inhibition of lps-induced nf-kappab activity, suppresses the tumor promoting function of ucp2 in a cellular model of warburg effect, produces blue colored pigments by binding to amino acids, inhibits toll-like receptor (tlr) signaling and the production of pro-inflammatory cytokines, preventing sepsis and increasing survival in animal models of infection, increases glucose-stimulated insulin secretion, mitochondrial membrane potential and atp levels in pancreatic island cells, increases bax/bcl-2 ratio and induces parp cleavage and caspase-3- and caspase-9-mediated apoptosis in non-small cell lung cancer (nsclc) cells, chemical promoter of epstein-barr virus (ebv) lytic cycle activation and suppressor of ebv infection, cell permeable inhibitor of uncoupling protein 2 (ucp2), sensitizes multidrug-resistant cancer cells to cytotoxic agents through ucp2 inhibition, inhibits nlrp3 and nlrc4 inflammasome activation via autophagy suppression, anticancer, antimetastatic and anti-angiogenic agent, anti-inflammatory agent.
Greater than 98% by HPLC
Genipin, (+)-Genipin, Methyl (1S,2R,6S)-2-hydroxy-9-(hydroxymethyl)-3-oxabicyclo[4.3.0]nona-4,8-diene-5-carboxylate
White to off-white solid.
Soluble in DMSO (50mg/ml), ethanol (5mg/ml), methanol or acetone. Slightly soluble in water.
Store at -20°C for up to 2 years. Protect from light. Protect from moisture.
For research use only.
Available for shipment within the USA only