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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Cell Cycle Pathways
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Catalog Number Size Price
LS-H758-25 25 µg $105 
LS-H758-100 100 µg $210 
LS-H758-1 1 mg $615 
Biochemical - Concanamycin A (high purity) Structure

Concanamycin A (high purity) (CAS 80890-47-7) - LS-H758

Concanamycin A (high purity) (CAS 80890-47-7) - LS-H758

Available for shipment within the USA only
Description:
Antibiotic. More potent and specific H+-ATPase inhibitor than bafilomycin A1. Inhibits acidification of organelles such as lysosomes and the Golgi apparatus. Inhibitor of autophagic degradation by rising lysosomal pH and thus inactivating the lysosomal acid hydrolases. Blocks cell surface expression of viral glycoproteins without affecting their synthesis. Cytotoxic in a number of cell lines in a cell viability assay. Induces nitric oxide (NO) production.
Price
Catalog Number
$105 
LS-H758-25

Available for shipment within the USA only
Toll Free North America
866-819-4732
For Research Use Only

Overview

Description:
Antibiotic. More potent and specific H+-ATPase inhibitor than bafilomycin A1. Inhibits acidification of organelles such as lysosomes and the Golgi apparatus. Inhibitor of autophagic degradation by rising lysosomal pH and thus inactivating the lysosomal acid hydrolases. Blocks cell surface expression of viral glycoproteins without affecting their synthesis. Cytotoxic in a number of cell lines in a cell viability assay. Induces nitric oxide (NO) production.

Specifications

Conjugations
Unconjugated
CAS Number
80890-47-7
Biological Function
more potent and specific h+-atpase inhibitor than bafilomycin a1, inhibits acidification of organelles such as lysosomes and the golgi apparatus, inhibitor of autophagic degradation by rising lysosomal ph and thus inactivating the lysosomal acid hydrolases, induces nitric oxide (no) production. antibiotic.
Purity
Greater than 99% by HPLC
Type
Concanamycin A (high purity), Antibiotic TAN 1323B, Antibiotic X4357B, Folimycin
Classification
Biochemical, Chemical
Molecular Formula
C46H75NO14
Molecular Weight
866.1
Formulation
White to off-white solid.
Solubility
Soluble in methanol, DMSO or acetonitrile; insoluble in water.
SMILES
[H][C@@]1(C[C@@H](O)[C@H](OC(N)=O)[C@@H](C)O1)O[C@@H]1C[C@@](O)(O[C@H](\C=C\C)[C@H]1C)[C@@H](C)[C@H](O)[C@H](C)[C@]1([H])OC(=O)\C(OC)=C\C(\C)=C\[C@@H](C)[C@@H](O)[C@@H](CC)[C@@H](O)[C@H](C)CC(C)=C\C=C\[C@@H]1OC
InChI Code
InChI=1S/C46H75NO14/c1-13-16-34-28(7)37(58-38-22-33(48)43(31(10)57-38)60-45(47)53)23-46(54,61-34)30(9)41(51)29(8)42-35(55-11)18-15-17-24(3)19-26(5)39(49)32(14-2)40(50)27(6)20-25(4)21-36(56-12)44(52)59-42/h13,15-18,20-21,26-35,37-43,48-51,54H,14,19,22-23H2
InChI Key
DJZCTUVALDDONK-MSPZYORZSA-N
Storage
Store at -20°C for 1 year. Protect from light. After reconstitution: Store at -20°C, protect from light.
Documents
Restrictions
For research use only. Available for shipment within the USA only
Guarantee
This Biochemical carries the LSBio 100% Guarantee

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Images

Biochemical - Concanamycin A (high purity) Structure
Concanamycin A (high purity) Structure

Biochemical - Concanamycin A (high purity) Structure
Concanamycin A (high purity) Structure

Biochemical - Concanamycin A (high purity) Structure
Concanamycin A (high purity) Structure

Biochemical - Concanamycin A (high purity) Structure
Concanamycin A (high purity) Structure

Requested From: United States
Date Requested: 2/28/2020