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Catalog Number Size Price
LS-H6971-5 5 mg $75 
LS-H6971-10 10 mg $130 
LS-H6971-25 25 mg $215 
ALLN Biochemical - Calpain Inhibitor I Structure

Calpain Inhibitor I (CAS 110044-82-1) - LS-H6971

Calpain Inhibitor I (CAS 110044-82-1) - LS-H6971

Available for shipment within the USA only
Description:
Calpain inhibitor I is a synthetic tripeptide aldehyde that acts as a potent inhibitor of cysteine proteases including calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM). At 10-100 µM calpain inhibitor I dose-dependently prevents the degradation of IKBAlpha and IKBBeta by the ubiquitin-proteasome complex, which blocks activation of NFKB and the production of TNF and IL-1Beta, suggesting a potential therapeutic effect for inflammatory diseases. At 10 µM, calpain inhibitor I can inhibit nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene.
Price
Catalog Number
$75 
LS-H6971-5

Available for shipment within the USA only
Toll Free North America
866-819-4732

Overview

Description:
Calpain inhibitor I is a synthetic tripeptide aldehyde that acts as a potent inhibitor of cysteine proteases including calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM). At 10-100 µM calpain inhibitor I dose-dependently prevents the degradation of IKBAlpha and IKBBeta by the ubiquitin-proteasome complex, which blocks activation of NFKB and the production of TNF and IL-1Beta, suggesting a potential therapeutic effect for inflammatory diseases. At 10 µM, calpain inhibitor I can inhibit nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene.

Specifications

CAS Number
110044-82-1
Biological Function
A non-selective cysteine protease inhibitor.
Purity
Greater than 95%
Formal Name
N-acetyl-L-leucyl-N-[(1S)-1-formylpentyl]-L-leucinamide
Type
Calpain Inhibitor I, Ac-Leu-Leu-Nle-Aldehyde, ALLN, MG 101
Classification
Biochemical, Chemical
Molecular Formula
C20H37N3O4
Molecular Weight
383.5 g/mol
Formulation
a crystalline solid
SMILES
CCCC[C@H](NC([C@@H](NC([C@@H](NC(C)=O)CC(C)C)=O)CC(C)C)=O)C=O
InChI Code
InChI=1S/C20H37N3O4/c1-7-8-9-16(12-24)22-19(26)18(11-14(4)5)23-20(27)17(10-13(2)3)21-15(6)25/h12-14,16-18H,7-11H2,1-6H3,(H,21,25)(H,22,26)(H,23,27)/t16-,17-,18-/m0/s1
InChI Key
FMYKJLXRRQTBOR-BZSNNMDCSA-N
Storage
Store at -20°C for up to 2 years.
Documents
Usage Information
Calpain inhibitor I is supplied as a crystalline solid. A stock solution may be made by dissolving the calpain inhibitor I in the solvent of choice. Calpain inhibitor I is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide, which should be purged with an inert gas. The solubility of calpain inhibitor I in these solvents is approximately 20 mg/ml. Calpain inhibitor I is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, calpain inhibitor I should first be dissolved in ethanol and then diluted with the aqueous buffer of choice. Calpain inhibitor I has a solubility of approximately 0.5 mg/ml in a 1:1 solution of ethanol:PBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day.
Restrictions
For research use only. Available for shipment within the USA only
Guarantee
This Biochemical carries the LSBio 100% Guarantee

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Images

ALLN Biochemical - Calpain Inhibitor I Structure
Calpain Inhibitor I Structure

ALLN Biochemical - Calpain Inhibitor I Structure
Calpain Inhibitor I Structure

ALLN Biochemical - Calpain Inhibitor I Structure
Calpain Inhibitor I Structure

ALLN Biochemical - Calpain Inhibitor I Structure
Calpain Inhibitor I Structure

Requested From: United States
Date Requested: 12/13/2019