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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Cell Cycle Pathways
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Catalog Number Size Price
LS-H667-250 250 µg $180 
LS-H667-1 1 mg $330 
Biochemical - beta-Mannosylceramide Structure

beta-Mannosylceramide (CAS 1334332-65-8) - LS-H667

beta-Mannosylceramide (CAS 1334332-65-8) - LS-H667

Available for shipment within the USA only
Description:
Potent stimulator of invariant natural killer T (iNKT) cells. Induces strong antitumor immunity through a nitric oxide (NO) and TNF-alpha dependent mechansim, different compared to the IFN-gamma dependent mechanism of alpha-GalCer. Does not induce anergy of iNKT cells.
Price
Catalog Number
$180 
LS-H667-250

Available for shipment within the USA only
Toll Free North America
866-819-4732
For Research Use Only

Overview

Description:
Potent stimulator of invariant natural killer T (iNKT) cells. Induces strong antitumor immunity through a nitric oxide (NO) and TNF-alpha dependent mechansim, different compared to the IFN-gamma dependent mechanism of alpha-GalCer. Does not induce anergy of iNKT cells.

Specifications

Conjugations
Unconjugated
CAS Number
1334332-65-8
Biological Function
induces strong antitumor immunity through a nitric oxide (no) and tnf-alpha dependent mechansim, different compared to the ifn-gamma dependent mechanism of alpha-galcer.
Purity
Greater than 95% by TLC, NMR
Type
beta-Mannosylceramide, (2S,3S,4R)-2-Amino-N-hexacosanoyl-1-O-(beta-D-mannopyranosyl)-1,3,4-octadecanetriol, beta-ManCer, beta-Mannosyl Ceramide
Classification
Biochemical, Chemical
Molecular Formula
C50H99NO9
Molecular Weight
858.3
Formulation
White to off-white solid.
Solubility
Soluble in pyridine or warm DMSO. Insoluble in water.
SMILES
CCCCCCCCCCCCCCCCCCCCCCCCCC(=O)N[C@@H](COC1OC(CO)C(O)C(O)C1O)[C@H](O)[C@H](O)CCCCCCCCCCCCCC
InChI Code
InChI=1S/C50H99NO9/c1-3-5-7-9-11-13-15-17-18-19-20-21-22-23-24-25-26-27-29-31-33-35-37-39-45(54)51-42(41-59-50-49(58)48(57)47(56)44(40-52)60-50)46(55)43(53)38-36-34-32-30-28-16-14-12-10-8-6-4-2/h42-44,46-50,52-53,55-58H,3-41H2,1-2H3,(H,51,54)/t42-,43+,44+
InChI Key
VQFKFAKEUMHBLV-JDMIZZMOSA-N
Storage
Store at -20°C for up to 2 years.
Documents
Usage Information
After reconstitution, prepare aliquots and store at -20°C. Aliquot into glass vials.
Restrictions
For research use only. Available for shipment within the USA only
Guarantee
This Biochemical carries the LSBio 100% Guarantee

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Biochemical - beta-Mannosylceramide Structure
beta-Mannosylceramide Structure

Biochemical - beta-Mannosylceramide Structure
beta-Mannosylceramide Structure

Biochemical - beta-Mannosylceramide Structure
beta-Mannosylceramide Structure

Biochemical - beta-Mannosylceramide Structure
beta-Mannosylceramide Structure

Requested From: United States
Date Requested: 2/28/2020