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Catalog Number Size Price
LS-H6762-5 5 mg $70 
LS-H6762-10 10 mg $115 
LS-H6762-25 25 mg $245 
LS-H6762-50 50 mg $435 
Ampalex Biochemical - BDP-12 Structure

BDP-12 (CAS 154235-83-3) - LS-H6762

BDP-12 (CAS 154235-83-3) - LS-H6762

Available for shipment within the USA only
Description:
BDP-12 is an AMPA receptor modulator. It increases the mean open time of AMPA receptors which increases the amplitude of trisynaptic responses to presynaptic stimulation in rat hippocampal slices. In vivo, BDP-12 (10-50 mg/kg) accelerates acquisition of a conditioned fear response in rats in a dose-dependent manner. It enhances performance in a spatial, delayed nonmatch-to-sample (DNMS) test in rats. BDP-12 also reverses dominance between initially dominant and submissive rat pairs, a marker of antidepressant-like activity, in the rat reduction of submissive behavior model.
Price
Catalog Number
$70 
LS-H6762-5

Available for shipment within the USA only
Toll Free North America
866-819-4732

Overview

Description:
BDP-12 is an AMPA receptor modulator. It increases the mean open time of AMPA receptors which increases the amplitude of trisynaptic responses to presynaptic stimulation in rat hippocampal slices. In vivo, BDP-12 (10-50 mg/kg) accelerates acquisition of a conditioned fear response in rats in a dose-dependent manner. It enhances performance in a spatial, delayed nonmatch-to-sample (DNMS) test in rats. BDP-12 also reverses dominance between initially dominant and submissive rat pairs, a marker of antidepressant-like activity, in the rat reduction of submissive behavior model.

Specifications

CAS Number
154235-83-3
Biological Function
An AMPA receptor modulator.
Purity
Greater than 98%
Formal Name
1-(6-quinoxalinylcarbonyl)-piperidine
Type
BDP-12, Ampalex, BDP-12, Benzoyl-Piperidine-12
Classification
Biochemical, Chemical
Molecular Formula
C14H15N3O
Molecular Weight
241.3 g/mol
Formulation
a crystalline solid
SMILES
O=C(C1=CC(N=CC=N2)=C2C=C1)N3CCCCC3
InChI Code
InChI=1S/C14H15N3O/c18-14(17-8-2-1-3-9-17)11-4-5-12-13(10-11)16-7-6-15-12/h4-7,10H,1-3,8-9H2
InChI Key
ANDGGVOPIJEHOF-UHFFFAOYSA-N
Storage
Store at -20°C for up to 2 years.
Documents
Usage Information
BDP-12 is supplied as a crystalline solid. A stock solution may be made by dissolving the BDP-12 in the solvent of choice. BDP-12 is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF), which should be purged with an inert gas. The solubility of BDP-12 in ethanol is approximately 10 mg/ml and approximately 50 mg/ml in DMSO and DMF. Further dilutions of the stock solution into aqueous buffers or isotonic saline should be made prior to performing biological experiments. Ensure that the residual amount of organic solvent is insignificant, since organic solvents may have physiological effects at low concentrations. Organic solvent-free aqueous solutions of BDP-12 can be prepared by directly dissolving the crystalline solid in aqueous buffers. The solubility of BDP-12 in PBS, pH 7.2, is approximately 5 mg/ml. We do not recommend storing the aqueous solution for more than one day.
Restrictions
For research use only. Available for shipment within the USA only
Guarantee
This Biochemical carries the LSBio 100% Guarantee

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Images

Ampalex Biochemical - BDP-12 Structure
BDP-12 Structure

Ampalex Biochemical - BDP-12 Structure
BDP-12 Structure

Ampalex Biochemical - BDP-12 Structure
BDP-12 Structure

Ampalex Biochemical - BDP-12 Structure
BDP-12 Structure

Requested From: United States
Date Requested: 12/12/2019