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Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Catalog Number Size Price
LS-H14607-10 10 mg $145 
LS-H14607-50 50 mg $510 
AT-101 Biochemical - AT-101 Structure

AT-101 (CAS 90141-22-3) - LS-H14607

AT-101 (CAS 90141-22-3) - LS-H14607

Available for shipment within the USA only
Description:
AT-101 is a small molecule mimic of the BH3 domain of cellular Bcl-2 inhibitors which interferes with the function of Bcl-2-family antiapoptotic proteins. AT-101 induces apoptosis in drug-resistant multiple myeloma cell lines. Apoptosis is activated by the mitochondrial pathway. Cell permeable.
Price
Catalog Number
$145 
LS-H14607-10

Available for shipment within the USA only
Toll Free North America
866-819-4732

Overview

Description:
AT-101 is a small molecule mimic of the BH3 domain of cellular Bcl-2 inhibitors which interferes with the function of Bcl-2-family antiapoptotic proteins. AT-101 induces apoptosis in drug-resistant multiple myeloma cell lines. Apoptosis is activated by the mitochondrial pathway. Cell permeable.

Specifications

CAS Number
90141-22-3
Biological Function
Bcl-2 inhibitor
Purity
Greater than 98% by NMR, TLC
Classification
Biochemical, Chemical, Inhibitor
Molecular Formula
C30H30O8
Molecular Weight
518.56
Formulation
Light brown solid
Solubility
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 50 mg/ml).
Storage
Store at -20°C. After dissolving store at -20°C for up to 1 month.
Stability
24 months
Documents
Restrictions
For research use only. Available for shipment within the USA only
Guarantee
This Biochemical carries the LSBio 100% Guarantee

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Images

AT-101 Biochemical - AT-101 Structure
AT-101 Structure

AT-101 Biochemical - AT-101 Structure
AT-101 Structure

AT-101 Biochemical - AT-101 Structure
AT-101 Structure

AT-101 Biochemical - AT-101 Structure
AT-101 Structure

Requested From: United States
Date Requested: 12/10/2019