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Catalog Number Size Price
LS-H14604-5 5 mg $70 
LS-H14604-25 25 mg $230 
AS-8351 Biochemical - AS-8351 Structure

AS-8351 (CAS 796-42-9) - LS-H14604

AS-8351 (CAS 796-42-9) - LS-H14604

Available for shipment within the USA only
Description:
AS-8351 has been used in a cocktail of nine small molecules used to efficiently induce cardiac reprogramming of human fibroblasts. It is believed that AS-8351 exerts its effects by modulating the activity of the JmjC domain-containing histone demethylases (JmjC-KDM). Thus each of the 22 genes in the JmjC-KDM family was abrogated using small hairpin RNAs which showed that only knocking down KDM5B (or using another KDM5B inhibitor such as PBIT) could phenocopy AS-8351 in generating cardiomyocytes. This strongly suggests that KDM5B is the target of AS-8351.
Price
Catalog Number
$70 
LS-H14604-5

Available for shipment within the USA only
Toll Free North America
866-819-4732

Overview

Description:
AS-8351 has been used in a cocktail of nine small molecules used to efficiently induce cardiac reprogramming of human fibroblasts. It is believed that AS-8351 exerts its effects by modulating the activity of the JmjC domain-containing histone demethylases (JmjC-KDM). Thus each of the 22 genes in the JmjC-KDM family was abrogated using small hairpin RNAs which showed that only knocking down KDM5B (or using another KDM5B inhibitor such as PBIT) could phenocopy AS-8351 in generating cardiomyocytes. This strongly suggests that KDM5B is the target of AS-8351.

Specifications

CAS Number
796-42-9
Biological Function
KDM5B histone demethylase inhibitor
Purity
Greater than 98% by NMR, TLC
Formal Name
2-Hydroxy-1-naphthylaldehyde isonicotinolyhydrazone
Classification
Biochemical, Chemical, Inhibitor
Molecular Formula
C17H13N3O2
Formulation
Yellow solid
Solubility
Soluble in DMSO (up to 45 mg/ml), in DMF (up to 30 mg/ml) or in Ethanol (up to 10 mg/ml with warming)
Storage
Store desiccated at -20°C. After dissolving store at -20°C for up to 1 month.
Stability
12 months
Documents
Restrictions
For research use only. Available for shipment within the USA only
Guarantee
This Biochemical carries the LSBio 100% Guarantee

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AS-8351 Biochemical - AS-8351 Structure
AS-8351 Structure

AS-8351 Biochemical - AS-8351 Structure
AS-8351 Structure

AS-8351 Biochemical - AS-8351 Structure
AS-8351 Structure

AS-8351 Biochemical - AS-8351 Structure
AS-8351 Structure

Requested From: United States
Date Requested: 12/9/2019