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Catalog Number Size Price
LS-H140-1 1 mg $75 
LS-H140-5 5 mg $270 
LS-H140-10 10 mg $380 
Biochemical - AR420626 Structure

AR420626 (CAS 1798310-55-0) - LS-H140

AR420626 (CAS 1798310-55-0) - LS-H140

Available for shipment within the USA only
Description:
Free fatty acid receptor 3 (FFAR3; GPR41) is a G protein-coupled receptor activated by short chain fatty acids (SCFAs). It is expressed in adipose tissue, the gastrointestinal tract, and the peripheral nervous system, and it is involved in SCFA-dependent energy regulation. AR420626 is a selective agonist of FFAR3 (GPR41; IC50 = 117 nM) that does not activate the related receptor FFAR2 (GPR43) at concentrations up to 100 µM. At 10 µM, it can stimulate a 1.26-fold increased release of glucagon-like peptide-1 from colonic crypt cultures.
Price
Catalog Number
$75 
LS-H140-1

Available for shipment within the USA only
Toll Free North America
866-819-4732
For Research Use Only

Overview

Description:
Free fatty acid receptor 3 (FFAR3; GPR41) is a G protein-coupled receptor activated by short chain fatty acids (SCFAs). It is expressed in adipose tissue, the gastrointestinal tract, and the peripheral nervous system, and it is involved in SCFA-dependent energy regulation. AR420626 is a selective agonist of FFAR3 (GPR41; IC50 = 117 nM) that does not activate the related receptor FFAR2 (GPR43) at concentrations up to 100 µM. At 10 µM, it can stimulate a 1.26-fold increased release of glucagon-like peptide-1 from colonic crypt cultures.

Specifications

Conjugations
Unconjugated
CAS Number
1798310-55-0
Biological Function
A selective FFAR3 (GPR41) agonist.
Purity
Greater than 94%
Formal Name
N-(2,5-dichlorophenyl)-4-(2-furanyl)-1,4,5,6,7,8-hexahydro-2-methyl-5-oxo-3-quinolinecarboxamide
Classification
Biochemical, Chemical, Agonist
Molecular Formula
C21H18Cl2N2O3
Molecular Weight
417.3
Formulation
Crystalline solid
Solubility
Soluble in organic solvents such as DMSO and dimethyl formamide, which should be purged with an inert gas. The solubility of AR420626 in these solvents is approximately 5 and 2 mg/ml, respectively.
λmax
212, 262, 358 nm
SMILES
ClC1=CC(NC(C2=C(C)NC(CCCC3=O)=C3C2C4=CC=CO4)=O)=C(Cl)C=C1
InChI Code
1S/C21H18Cl2N2O3/c1-11-18(21(27)25-15-10-12(22)7-8-13(15)23)20(17-6-3-9-28-17)19-14(24-11)4-2-5-16(19)26/h3,6-10,20,24H,2,4-5H2,1H3,(H,25,27)
InChI Key
GGTYQECCGLBHGS-UHFFFAOYSA-N
Storage
Store at -20°C.
Stability
24 months
Documents
Usage Information
AR420626 is supplied as a crystalline solid. A stock solution may be made by dissolving the AR420626 in the solvent of choice. AR420626 is soluble in organic solvents such as DMSO and dimethyl formamide, which should be purged with an inert gas. The solubility of AR420626 in these solvents is approximately 5 and 2 mg/ml, respectively. AR420626 is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, AR420626 should first be dissolved in DMSO and then diluted with the aqueous buffer of choice. AR420626 has a solubility of approximately 0.2 mg/ml in a 1:4 solution of DMSO:PBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day.
Restrictions
For research use only. Available for shipment within the USA only
Guarantee
This Biochemical carries the LSBio 100% Guarantee

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Biochemical - AR420626 Structure
AR420626 Structure

Biochemical - AR420626 Structure
AR420626 Structure

Biochemical - AR420626 Structure
AR420626 Structure

Biochemical - AR420626 Structure
AR420626 Structure

Requested From: United States
Date Requested: 2/28/2020