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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Apoptosis activator 2 (CAS 79183-19-0)

Available for shipment within the USA only
Catalog
Size
Price
LS-H3329-5
5 mg
$105
LS-H3329-25
25 mg
$360

Available for shipment within the USA only

Product Description

Apoptosis activator 2 is a cell-permeable apoptosis activator that promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome. Increases procaspase-9 processing and subsequent caspase-3 activation. Induces apoptosis in tumor cells (IC50 = 4 - 9 MM for leukemia cells) with weak or no effect on normal cell lines or those defective/deficient in Apaf-1, caspase-9 or caspase-3 activity (IC50 > 40 MM).

Specifications

CAS Number
79183-19-0
Biological Function
Apoptosis activator
Purity
Greater than 98% by HPLC
Synonyms
Apoptosis activator 2, 1-[(3,4-dichlorophenyl)methyl]indole-2,3-dione
Classification
Biochemical, Chemical
PubChem CID
1901244
Molecular Formula
C15H9Cl2NO2
Molecular Weight
306.14
Formulation
Orange solid.
Solubility
DMSO (~ 30 mg/ml)
SMILES
C1=CC=C2C(=C1)C(=O)C(=O)N2CC3=CC(=C(C=C3)Cl)Cl
InChI Code
InChI=1S/C15H9Cl2NO2/c16-11-6-5-9(7-12(11)17)8-18-13-4-2-1-3-10(13)14(19)15(18)20/h1-7H,8H2
InChI Key
KGRJPLRFGLMQMV-UHFFFAOYSA-N
Storage
Store at -20°C. Protect from air. Protect from light.
Stability
3 years
Documents
SDS SDS
Restrictions
This product is for research use only. Not for administration to humans, or for human or veterinary diagnostic or therapeutic use.
Available for shipment within the USA only.

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TG101348: A potent JAK2 inhibitor
TG101348: A potent JAK2 inhibitor

TG101348: A potent JAK2 inhibitor
TG101348: A potent JAK2 inhibitor

TG101348: A potent JAK2 inhibitor
TG101348: A potent JAK2 inhibitor

TG101348: A potent JAK2 inhibitor
TG101348: A potent JAK2 inhibitor

Requested From: United States
Date Requested: 1/21/2019
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