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Catalog Number Size Price
LS-H6496-1 1 mg $60 
LS-H6496-5 5 mg $180 
LS-H6496-10 10 mg $315 
Amastatin Hydrochloride Biochemical - Amastatin (hydrochloride) Structure

Amastatin (hydrochloride) (CAS 100938-10-1) - LS-H6496

Amastatin (hydrochloride) (CAS 100938-10-1) - LS-H6496

Available for shipment within the USA only
Description:
Amastatin is a slow, tight binding, competitive aminopeptidase (AP) inhibitor, first described as an inhibitor of human serum AP-A (glutamyl AP; IC50 = 0.54 µg/ml) but not of AP-B (arginine AP). It also inhibits AP-N (AP-M, alanyl AP; Ki = 20-200 nM), leucyl-cystinyl AP (Ki = 20-220 nM), and endoplasmic reticulum AP 1 (Ki = 41.8 µM). Amastatin is without effect on trypsin, papain, chymotrypsin, elastase, pepsin, or thermolysin.
Price
Catalog Number
$60 
LS-H6496-1

Available for shipment within the USA only
Toll Free North America
866-819-4732

Overview

Description:
Amastatin is a slow, tight binding, competitive aminopeptidase (AP) inhibitor, first described as an inhibitor of human serum AP-A (glutamyl AP; IC50 = 0.54 µg/ml) but not of AP-B (arginine AP). It also inhibits AP-N (AP-M, alanyl AP; Ki = 20-200 nM), leucyl-cystinyl AP (Ki = 20-220 nM), and endoplasmic reticulum AP 1 (Ki = 41.8 µM). Amastatin is without effect on trypsin, papain, chymotrypsin, elastase, pepsin, or thermolysin.

Specifications

CAS Number
100938-10-1
Biological Function
An aminopeptidase inhibitor.
Purity
Greater than 95%
Formal Name
N-[(2S,3R)-3-amino-2-hydroxy-5-methyl-1-oxohexyl]-L-valyl-L-valyl-L-aspartic acid, monohydrochloride
Classification
Biochemical, Chemical
Molecular Formula
C21H38N4O8• HCl
Molecular Weight
511.0 g/mol
Formulation
a crystalline solid
SMILES
CC(C)[C@H](NC([C@@H](NC([C@@H](O)[C@H](N)CC(C)C)=O)C(C)C)=O)C(N[C@@H](CC(O)=O)C(O)=O)=O.Cl
InChI Code
InChI=1S/C21H38N4O8.ClH/c1-9(2)7-12(22)17(28)20(31)25-16(11(5)6)19(30)24-15(10(3)4)18(29)23-13(21(32)33)8-14(26)27;/h9-13,15-17,28H,7-8,22H2,1-6H3,(H,23,29)(H,24,30)(H,25,31)(H,26,27)(H,32,33);1H/t12-,13+,15+,16+,17+;/m1./s1
InChI Key
GBDUPCKQTDKNLS-PORDUOSCSA-N
Storage
Store at -20°C for up to 2 years.
Documents
Usage Information
Amastatin (hydrochloride) is supplied as a crystalline solid. A stock solution may be made by dissolving the amastatin (hydrochloride) in the solvent of choice. Amastatin (hydrochloride) is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide, which should be purged with an inert gas. The solubility of amastatin (hydrochloride) in these solvents is approximately 1, 2, and 10 mg/ml, respectively. Further dilutions of the stock solution into aqueous buffers or isotonic saline should be made prior to performing biological experiments. Ensure that the residual amount of organic solvent is insignificant, since organic solvents may have physiological effects at low concentrations. Organic solvent-free aqueous solutions of amastatin (hydrochloride) can be prepared by directly dissolving the crystalline solid in aqueous buffers. The solubility of amastatin (hydrochloride) in PBS, pH 7.2, is approximately 5 mg/ml. We do not recommend storing the aqueous solution for more than one day.
Restrictions
For research use only. Available for shipment within the USA only
Guarantee
This Biochemical carries the LSBio 100% Guarantee

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Images

Amastatin Hydrochloride Biochemical - Amastatin (hydrochloride) Structure
Amastatin (hydrochloride) Structure

Amastatin Hydrochloride Biochemical - Amastatin (hydrochloride) Structure
Amastatin (hydrochloride) Structure

Amastatin Hydrochloride Biochemical - Amastatin (hydrochloride) Structure
Amastatin (hydrochloride) Structure

Amastatin Hydrochloride Biochemical - Amastatin (hydrochloride) Structure
Amastatin (hydrochloride) Structure

Requested From: United States
Date Requested: 12/9/2019