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Catalog Number Size Price
LS-H3113-5 5 mg $140 
ALLN Biochemical - MDL 28170: A potent calpain and cathepsin B inhibitor

ALLN (CAS 110044-82-1) - LS-H3113

ALLN (CAS 110044-82-1) - LS-H3113

Available for shipment within the USA only
Description:
A cell-permeable inhibitor of calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 0.5 nM). Inhibits neutral cysteine proteases and the proteasome (Ki = 6 µM). Can initiate apoptosis in HL-60 cells but blocks dexamethasone-induced apoptosis in thymocytes and cycloheximide-induced apoptosis in metamyelocytes. Inhibits cyclin B degradation and arrests the cell cycle at G1/S and at meta-/anaphase.
Price
Catalog Number
$140 
LS-H3113-5
5 mg

Available for shipment within the USA only
Toll Free North America
866-819-4732

Overview

Description:
A cell-permeable inhibitor of calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 0.5 nM). Inhibits neutral cysteine proteases and the proteasome (Ki = 6 µM). Can initiate apoptosis in HL-60 cells but blocks dexamethasone-induced apoptosis in thymocytes and cycloheximide-induced apoptosis in metamyelocytes. Inhibits cyclin B degradation and arrests the cell cycle at G1/S and at meta-/anaphase.

Specifications

CAS Number
110044-82-1
Biological Function
Calpain inhibitor
Purity
Greater than 95% by HPLC
Type
ALLN, N-Acetyl-Leu-Leu-Nle-al, N-Acetyl-L-leucyl-L-leucyl-L-norleucinal, Ac-LLnL-CHO, MG-101
Classification
Biochemical, Chemical, Inhibitor
PubChem CID
443118
Molecular Formula
C20H37N3O4
Molecular Weight
383.54
Formulation
Liquid
SMILES
CCCCC(C=O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C
InChI Code
InChI=1S/C20H37N3O4/c1-7-8-9-16(12-24)22-19(26)18(11-14(4)5)23-20(27)17(10-13(2)3)21-15(6)25/h12-14,16-18H,7-11H2,1-6H3,(H,21,25)(H,22,26)(H,23,27)/t16-,17-,18-/m0/s1
InChI Key
FMYKJLXRRQTBOR-BZSNNMDCSA-N
Sequence
Ac-Leu-Leu-Nile-CHO
Storage
Store at -20°C. Protect from air. Protect from moisture.
Stability
12 months
Documents
Restrictions
For research use only. Available for shipment within the USA only
Guarantee
This Biochemical carries the LSBio 100% Guarantee

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ALLN Biochemical - MDL 28170: A potent calpain and cathepsin B inhibitor
MDL 28170: A potent calpain and cathepsin B inhibitor

ALLN Biochemical - MDL 28170: A potent calpain and cathepsin B inhibitor
MDL 28170: A potent calpain and cathepsin B inhibitor

ALLN Biochemical - MDL 28170: A potent calpain and cathepsin B inhibitor
MDL 28170: A potent calpain and cathepsin B inhibitor

ALLN Biochemical - MDL 28170: A potent calpain and cathepsin B inhibitor
MDL 28170: A potent calpain and cathepsin B inhibitor

Requested From: United States
Date Requested: 12/12/2019