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Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Catalog Number Size Price
LS-H14590-5 5 mg $70 
LS-H14590-25 25 mg $210 
AK-7 Biochemical - AK-7 Structure

AK-7 (CAS 420831-40-9) - LS-H14590

AK-7 (CAS 420831-40-9) - LS-H14590

Available for shipment within the USA only
Description:
AK-7 is a selective Sirt2 inhibitor (IC50=15.5 uM) which does not inhibit Sirt1 or Sirt3. It down regulates cholesterol biosynthesis genes in primary striatal neurons. AK-7 displays neuroprotective effects in Huntington's disease mouse models including improved motor function, extended survival and reduced brain atrophy all of which were associated with reduced aggregated mutant huntingtin.
Price
Catalog Number
$70 
LS-H14590-5

Available for shipment within the USA only
Toll Free North America
866-819-4732

Overview

Description:
AK-7 is a selective Sirt2 inhibitor (IC50=15.5 uM) which does not inhibit Sirt1 or Sirt3. It down regulates cholesterol biosynthesis genes in primary striatal neurons. AK-7 displays neuroprotective effects in Huntington's disease mouse models including improved motor function, extended survival and reduced brain atrophy all of which were associated with reduced aggregated mutant huntingtin.

Specifications

CAS Number
420831-40-9
Biological Function
SIRT2 inhibitor
Purity
Greater than 98% by NMR, TLC
Formal Name
3-(1-Azepanylsulfonyl)-N-(3-bromophenyl)benzamide
Classification
Biochemical, Chemical, Inhibitor
Molecular Formula
C19H21BrN2O3S
Molecular Weight
437.36
Formulation
White solid
Solubility
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 8 mg/ml with warming).
Storage
Store desiccated at room temperature. After dissolving store at -20°C for up to 3 months.
Stability
36 months
Documents
Restrictions
For research use only. Available for shipment within the USA only
Guarantee
This Biochemical carries the LSBio 100% Guarantee

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Images

AK-7 Biochemical - AK-7 Structure
AK-7 Structure

AK-7 Biochemical - AK-7 Structure
AK-7 Structure

AK-7 Biochemical - AK-7 Structure
AK-7 Structure

AK-7 Biochemical - AK-7 Structure
AK-7 Structure

Requested From: United States
Date Requested: 12/11/2019