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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Cell Cycle Pathways
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Catalog Number Size Price
LS-H14490-5 5 mg $90 
LS-H14490-25 25 mg $330 
AI-3 Biochemical - AI-3 Structure

AI-3 (CAS 882288-28-0) - LS-H14490

AI-3 (CAS 882288-28-0) - LS-H14490

Available for shipment within the USA only
Description:
AI-3 is an activator of antioxidant response element (ARE) which induces cytoprotective genes in human cells. It alkylates Keap1 at Cys151 and is reactive toward additional cysteines at higher concentrations. Disrupts Nrf2/Keap1 and Keap1/Cul3 interactions and stabilizes Nrf2. AI-3 activates ARE in an Nrf2 and PI 3-kinase dependent manner. Cell permeable and active in vivo. MP = 71-74°C
Price
Catalog Number
$90 
LS-H14490-5

Available for shipment within the USA only
Toll Free North America
866-819-4732

Overview

Description:
AI-3 is an activator of antioxidant response element (ARE) which induces cytoprotective genes in human cells. It alkylates Keap1 at Cys151 and is reactive toward additional cysteines at higher concentrations. Disrupts Nrf2/Keap1 and Keap1/Cul3 interactions and stabilizes Nrf2. AI-3 activates ARE in an Nrf2 and PI 3-kinase dependent manner. Cell permeable and active in vivo. MP = 71-74°C

Specifications

CAS Number
882288-28-0
Biological Function
ARE activator
Purity
Greater than 98% by NMR, TLC
Formal Name
1-Chloro-6,7-dihydro-6,6-dimethyl-3-(methylsulfonyl)-benzo[c]thiophen-4(5H)-one
Classification
Biochemical, Chemical
Molecular Formula
C11H13ClO3S2
Molecular Weight
292.81
Formulation
White solid
Solubility
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 25 mg/ml).
Storage
Store desiccated at -20°C. After dissolving store at -20°C for up to 1 month.
Stability
24 months
Documents
Restrictions
For research use only. Available for shipment within the USA only
Guarantee
This Biochemical carries the LSBio 100% Guarantee

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Images

AI-3 Biochemical - AI-3 Structure
AI-3 Structure

AI-3 Biochemical - AI-3 Structure
AI-3 Structure

AI-3 Biochemical - AI-3 Structure
AI-3 Structure

AI-3 Biochemical - AI-3 Structure
AI-3 Structure

Requested From: United States
Date Requested: 12/9/2019