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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Cell Cycle Pathways
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Catalog Number Size Price
LS-H14589-5 5 mg $85 
LS-H14589-25 25 mg $310 
AI-1 Biochemical - AI-1 Structure

AI-1 (CAS 75483-04-4) - LS-H14589

AI-1 (CAS 75483-04-4) - LS-H14589

Available for shipment within the USA only
Description:
AI-1 is a novel antioxidant response element (ARE) activator which activates Nrf2 by covalently modifying Keap1 (Kelch-like ECH-associated protein 1) a negative regulator of Nrf2. Modification of Cys151 of Keap1 by AI-1 disrupts the ability of Keap1 to searve as an adaptor for Cul3-Keap1 ubiquitin ligase complex, thereby stabilizing and inducing transcriptional activation of Nrf2. AI-1 is a useful pharmacological tool for probing the involvement of Nrf2 in cellular physiology. Cell permeable.
Price
Catalog Number
$85 
LS-H14589-5

Available for shipment within the USA only
Toll Free North America
866-819-4732

Overview

Description:
AI-1 is a novel antioxidant response element (ARE) activator which activates Nrf2 by covalently modifying Keap1 (Kelch-like ECH-associated protein 1) a negative regulator of Nrf2. Modification of Cys151 of Keap1 by AI-1 disrupts the ability of Keap1 to searve as an adaptor for Cul3-Keap1 ubiquitin ligase complex, thereby stabilizing and inducing transcriptional activation of Nrf2. AI-1 is a useful pharmacological tool for probing the involvement of Nrf2 in cellular physiology. Cell permeable.

Specifications

CAS Number
75483-04-4
Biological Function
Nrf2 activator
Purity
Greater than 98% (NMR, HPLC)
Formal Name
4-Chloro-1,2-dihydro-1-methyl-2-oxo-3-quinolinecarboxylic acid ethyl ester
Classification
Biochemical, Chemical
Molecular Formula
C13H12ClNO3
Molecular Weight
265.70
Formulation
Off-white solid
Solubility
Soluble in DMSO (up to 15 mg/ml).
Storage
Store desiccated at -20°C. After dissolving store at -20°C for up to 3 months.
Stability
24 months
Documents
Restrictions
For research use only. Available for shipment within the USA only
Guarantee
This Biochemical carries the LSBio 100% Guarantee

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Images

AI-1 Biochemical - AI-1 Structure
AI-1 Structure

AI-1 Biochemical - AI-1 Structure
AI-1 Structure

AI-1 Biochemical - AI-1 Structure
AI-1 Structure

AI-1 Biochemical - AI-1 Structure
AI-1 Structure

Requested From: United States
Date Requested: 12/9/2019